ArticleThe Journal of experimental medicine2008
Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.
Article in The Journal of experimental medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 55 citations in OpenAlex.
- Ly49G, but not Ly49C/I, is dispensable for diverse antigen-specific memory NK cell responses in H-2d and H-2b mice.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function.Frontiers in immunology · 2024Article
- Guidelines for mouse and human DC generation.European journal of immunology · 2023Article
- Human leukocyte immunoglobulin-like receptors in health and disease.Frontiers in immunology · 2023Review
- Licensing Natural Killers for Antiviral Immunity.Pathogens (Basel, Switzerland) · 2021Review
- Type I Interferon Production of Plasmacytoid Dendritic Cells under Control.International journal of molecular sciences · 2021Review
- Plasmacytoid dendritic cells in the eye.Progress in retinal and eye research · 2021Review
- NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections.Cellular & molecular immunology · 2019Article
- SLAMF9 regulates pDC homeostasis and function in health and disease.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Understanding and Modulating Immunity With Cell Reprogramming.Frontiers in immunology · 2019Review
- Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Src family kinases Fyn and Lyn are constitutively activated and mediate plasmacytoid dendritic cell responses.Nature communications · 2017Article
- A distinct innate lymphoid cell population regulates tumor-associated T cells.Nature medicine · 2017Article
- Increased Abundance of Plasmacytoid Dendritic Cells and Interferon-Alpha Induces Plasma Cell Differentiation in Patients of IgA Nephropathy.Mediators of inflammation · 2017Article
- Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion.PLoS pathogens · 2016Article
- Estrogen Receptor α Deficiency Modulates TLR Ligand-Mediated PDC-TREM Expression in Plasmacytoid Dendritic Cells in Lupus-Prone Mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The multifaceted biology of plasmacytoid dendritic cells.Nature reviews. Immunology · 2015Review
- CD244 is expressed on dendritic cells and regulates their functions.Immunology and cell biology · 2015Article
- Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- Specific dysregulation of IFNγ production by natural killer cells confers susceptibility to viral infection.PLoS pathogens · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Plasmacytoid dendritic cells (pDCs) are an important source of type I interferon (IFN) during initial immune responses to viral infections. In mice, pDCs are uniquely characterized by high-level expression of Ly49Q, a C-type lectin-like receptor specific for class I major histocompatibility complex (MHC) molecules. Despite having a cytoplasmic immunoreceptor tyrosine-based inhibitory motif, Ly49Q was found to enhance pDC function in vitro, as pDC cytokine production in response to the Toll-like receptor (TLR) 9 agonist CpG-oligonucleotide (ODN) could be blocked using soluble monoclonal antibody (mAb) to Ly49Q or H-2K(b). Conversely, CpG-ODN-dependent IFN-alpha production by pDCs was greatly augmented upon receptor cross-linking using immobilized anti-Ly49Q mAb or recombinant H-2K(b) ligand. Accordingly, Ly49Q-deficient pDCs displayed a severely reduced capacity to produce cytokines in response to TLR7 and TLR9 stimulation both in vitro and in vivo. Finally, TLR9-dependent antiviral responses were compromised in Ly49Q-null mice infected with mouse cytomegalovirus. Thus, class I MHC recognition by Ly49Q on pDCs is necessary for optimal activation of innate immune responses in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.