ArticleProceedings of the National Academy of Sciences of the United States of America2008
Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Neurotropic and modulatory effects of insulin-like growth factor II in Aplysia.Scientific reports · 2019Article
- The neural circuit linking mushroom body parallel circuits induces memory consolidation inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Emergent memory in cell signaling: Persistent adaptive dynamics in cascades can arise from the diversity of relaxation time-scales.Scientific reports · 2018Article
- Appetitive Olfactory Learning and Long-Term Associative Memory inFrontiers in behavioral neuroscience · 2017Article
- Sustained Hypoxia Elicits Competing Spinal Mechanisms of Phrenic Motor Facilitation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The Contribution of Spatial and Temporal Molecular Networks in the Induction of Long-term Memory and Its Underlying Synaptic Plasticity.AIMS neuroscience · 2016Article
- Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- A novel cysteine-rich neurotrophic factor in Aplysia facilitates growth, MAPK activation, and long-term synaptic facilitation.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Activity-dependent inhibitory gating in molecular signaling cascades induces a novel form of intermediate-term synaptic facilitation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Pattern and predictability in memory formation: from molecular mechanisms to clinical relevance.Neurobiology of learning and memory · 2013Review
- Growth factor signaling and memory formation: temporal and spatial integration of a molecular network.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Review
- An Aplysia Egr homolog is rapidly and persistently regulated by long-term sensitization training.Neurobiology of learning and memory · 2013Article
- Local synaptic integration of mitogen-activated protein kinase and protein kinase A signaling mediates intermediate-term synaptic facilitation in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Molecular characterization and expression profile of MAP2K1ip1/MP1 gene from tiger shrimp, Penaeus monodon.Molecular biology reports · 2012Article
- Aversive olfactory learning and associative long-term memory in Caenorhabditis elegans.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Plk2 Raps up Ras to subdue synapses.Small GTPases · 2011Article
- Postinduction requirement of NMDA receptor activation for late-phase long-term potentiation of developing retinotectal synapses in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The tail-elicited tail withdrawal reflex of Aplysia is mediated centrally at tail sensory-motor synapses and exhibits sensitization across multiple temporal domains.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins.Neuron · 2010Review
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Memory formation is highly sensitive to specific patterns of training, but the cellular and molecular mechanisms underlying pattern sensitivity are not well understood. We explored this general question by using Aplysia californica as a model system. We examined the regulation of MAPK (ERK1/2) activation by small G proteins in the CNS by using different patterns of analog stimuli that mimic different patterns of behavioral training for memory induction. We first cloned and characterized the Aplysia homologs of the small G proteins, Ras and Rap1 (ApRas and ApRap, respectively). We next examined changes in ApRas and ApRap activity that accompany MAPK activation. Last, by delivering recombinant ApRas and ApRap into the CNS, we directly manipulated their activity and examined the resultant MAPK activation. We found that MAPK activation induced by analog training depends on the combined activity of ApRas and ApRap, rather than the individual activity of either one alone. Also, ApRas and ApRap have a complex role in MAPK activation: they can act as activators or inhibitors, depending on the specific pattern of the training. The pattern-sensitive regulation of MAPK by interactive ApRas and ApRap activity that we have identified could contribute to the molecular routing of different downstream effects of spatially localized MAPK required for the induction of specific pattern-sensitive forms of synaptic facilitation and memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.