ArticleProceedings of the National Academy of Sciences of the United States of America2008
Protein kinase A inhibits a consolidated form of memory in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Disruption of a selective vesicle pool upon retrograde amnesia dissociates memory at presynaptic terminals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Enhanced memory despite severe sleep loss in Drosophila insomniac mutants.PLoS biology · 2025Article
- Memory-like states created by the first ethanol experience are encoded into the Drosophila mushroom body learning and memory circuitry in an ethanol-specific manner.PLoS genetics · 2025Article
- Genetics and Molecular Biology of Memory Suppression.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Anesthesia Resistant Memories in Drosophila, a Working Perspective.International journal of molecular sciences · 2022Review
- Memory regulation in feeding habit transformation to dead prey fish of Chinese perch (Siniperca chuatsi).Fish physiology and biochemistry · 2021Article
- Review
- Effects of aversive conditioning on expression of physiological stress in honey bees (Apis mellifera).Neurobiology of learning and memory · 2021Article
- Typical neurobehavioral methods and transcriptome analysis reveal the neurotoxicity and mechanisms of di(2-ethylhexyl) phthalate on pubertal male ICR mice with type 2 diabetes mellitus.Archives of toxicology · 2020Article
- Article
- Inhibiting Glutamate Activity during Consolidation Suppresses Age-Related Long-Term Memory Impairment in Drosophila.iScience · 2019Article
- Electrical synapses between mushroom body neurons are critical for consolidated memory retrieval in Drosophila.PLoS genetics · 2019Article
- Drk-mediated signaling to Rho kinase is required for anesthesia-resistant memory inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Phosphoproteome Analysis Reveals Phosphorylation Underpinnings in the Brains of Nurse and Forager Honeybees (Apis mellifera).Scientific reports · 2017Article
- Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.PLoS genetics · 2016Article
- Consolidated and labile odor memory are separately encoded within the Drosophila brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Circadian modulation of consolidated memory retrieval following sleep deprivation in Drosophila.Sleep · 2012Article
- Slow oscillations in two pairs of dopaminergic neurons gate long-term memory formation in Drosophila.Nature neuroscience · 2012Article
- Bruchpilot, a synaptic active zone protein for anesthesia-resistant memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing activity of the cAMP/protein kinase A (PKA) pathway has often been proposed as an approach to improve memory in various organisms. However, here we demonstrate that single-point mutations, which decrease PKA activity, dramatically improve aversive olfactory memory in Drosophila. These mutations do not affect formation of early memory phases or of protein synthesis-dependent long-term memory but do cause a significant increase in a specific consolidated form of memory, anesthesia-resistant memory. Significantly, heterozygotes of null mutations in PKA are sufficient to cause this memory increase. Expressing a PKA transgene in the mushroom bodies, brain structures critical for memory formation in Drosophila, reduces memory back to wild-type levels. These results indicate that although PKA is critical for formation of several memory phases, it also functions to inhibit at least one memory phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.