ArticleThe Journal of cell biology2008
The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 51 citations in OpenAlex.
- Promotion of tumor angiogenesis and growth induced by low-dose antineoplastic agents via bone-marrow-derived cells in tumor tissues.Frontiers in pharmacology · 2024Article
- Mechanisms of angiogenesis in tumour.Frontiers in oncology · 2024Review
- Bone Niches, Hematopoietic Stem Cells, and Vessel Formation.International journal of molecular sciences · 2017Review
- Novel roles of Src in cancer cell epithelial-to-mesenchymal transition, vascular permeability, microinvasion and metastasis.Life sciences · 2016Review
- Identification of an Endogenously Generated Cryptic Collagen Epitope (XL313) That May Selectively Regulate Angiogenesis by an Integrin Yes-associated Protein (YAP) Mechano-transduction Pathway.The Journal of biological chemistry · 2016Article
- Receptor-Mediated Mechanism Controlling Tissue Levels of Bioactive Lipid Oxidation Products.Circulation research · 2015Article
- Article
- Impaired integrin β3 delays endothelial cell regeneration and contributes to arteriovenous graft failure in mice.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Article
- Clinically relevant doses of candesartan inhibit growth of prostate tumor xenografts in vivo through modulation of tumor angiogenesis.The Journal of pharmacology and experimental therapeutics · 2014Article
- Platelets govern pre-metastatic tumor communication to bone.Oncogene · 2013Article
- Akt1 mediates prostate cancer cell microinvasion and chemotaxis to metastatic stimuli via integrin β₃ affinity modulation.British journal of cancer · 2012Article
- αV integrins in angiogenesis and cancer.Cold Spring Harbor perspectives in medicine · 2011Review
- Angiogenesis.Cold Spring Harbor perspectives in biology · 2011Review
- Article
- Review
- Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands.Nature · 2010Article
- Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Integrins in cancer: biological implications and therapeutic opportunities.Nature reviews. Cancer · 2010Review
- Integrins as "functional hubs" in the regulation of pathological angiogenesis.Seminars in cancer biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Angiogenesis is dependent on the coordinated action of numerous cell types. A key adhesion molecule expressed by these cells is the alpha(v)beta(3) integrin. Here, we show that although this receptor is present on most vascular and blood cells, the key regulatory function in tumor and wound angiogenesis is performed by beta(3) integrin on bone marrow-derived cells (BMDCs) recruited to sites of neovascularization. Using knockin mice expressing functionally stunted beta(3) integrin, we show that bone marrow transplantation rescues impaired angiogenesis in these mice by normalizing BMDC recruitment. We demonstrate that alpha(v)beta(3) integrin enhances BMDC recruitment and retention at angiogenic sites by mediating cellular adhesion and transmigration of BMDCs through the endothelial monolayer but not their release from the bone niche. Thus, beta(3) integrin has the potential to control processes such as tumor growth and wound healing by regulating BMDC recruitment to sites undergoing pathological and adaptive angiogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.