ArticleThe Journal of cell biology2008
Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic.
Article in The Journal of cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Force-induced changes of α-catenin conformation stabilize vascular junctions independently of vinculin.Journal of cell science · 2021Article
- Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons.Nature communications · 2021Article
- Sevoflurane inhibits neuronal migration and axon growth in the developing mouse cerebral cortex.Aging · 2020Article
- So far, yet so close: α-Catenin dimers help migrating cells get together.The Journal of cell biology · 2017Article
- Llgl1 Connects Cell Polarity with Cell-Cell Adhesion in Embryonic Neural Stem Cells.Developmental cell · 2017Article
- GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors.Neuron · 2017Article
- αE-catenin inhibits a Src-YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway.Genes & development · 2016Article
- NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin.The Journal of cell biology · 2015Article
- Cadherin signaling: keeping cells in touch.F1000Research · 2015Review
- α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.Nature cell biology · 2014Article
- Regulation of classical cadherin membrane expression and F-actin assembly by alpha-catenins, during Xenopus embryogenesis.PloS one · 2012Article
- The secret life of α-catenin: moonlighting in morphogenesis.The Journal of cell biology · 2011Review
- Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development.Molecular and cellular biology · 2011Article
- α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1.Science signaling · 2011Article
- N-cadherin-mediated cell adhesion restricts cell proliferation in the dorsal neural tube.Molecular biology of the cell · 2011Article
- Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation.Physiological reviews · 2011Review
- The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.Developmental cell · 2010Article
- Intercellular junction assembly, dynamics, and homeostasis.Cold Spring Harbor perspectives in biology · 2010Review
- Myc-regulated microRNAs attenuate embryonic stem cell differentiation.The EMBO journal · 2009Article
- Remodeling epithelial cell organization: transitions between front-rear and apical-basal polarity.Cold Spring Harbor perspectives in biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Alpha-epithelial catenin (E-catenin) is an important cell-cell adhesion protein. In this study, we show that alpha-E-catenin also regulates intracellular traffic by binding to the dynactin complex component dynamitin. Dynactin-mediated organelle trafficking is increased in alpha-E-catenin(-/-) keratinocytes, an effect that is reversed by expression of exogenous alpha-E-catenin. Disruption of adherens junctions in low-calcium media does not affect dynactin-mediated traffic, indicating that alpha-E-catenin regulates traffic independently from its function in cell-cell adhesion. Although neither the integrity of dynactin-dynein complexes nor their association with vesicles is affected by alpha-E-catenin, alpha-E-catenin is necessary for the attenuation of microtubule-dependent trafficking by the actin cytoskeleton. Because the actin-binding domain of alpha-E-catenin is necessary for this regulation, we hypothesize that alpha-E-catenin functions as a dynamic link between the dynactin complex and actin and, thus, integrates the microtubule and actin cytoskeleton during intracellular trafficking.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.