ArticleDiabetes2009
C-reactive protein and 5-year survival in type 2 diabetes: the Casale Monferrato Study.
Article in Diabetes, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Association of tooth loss with morbidity and mortality by diabetes status in older adults: a systematic review.BMC endocrine disorders · 2021Pooled it
- High-sensitivity C-reactive protein, low-density lipoprotein cholesterol and cardiovascular outcomes in patients with type 2 diabetes in the EXAMINE (Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care) trial.Diabetes, obesity & metabolism · 2018Trial
- Trial
- Inflammation and Cardiovascular Risk: A Systematic Review of High-Sensitivity CRP as a Prognostic Indicator.Cureus · 2026Review
- Metabolic syndrome and high-sensitivity C-reactive protein co-modify the risk of coronary artery calcification.Frontiers in cardiovascular medicine · 2026Article
- Elevated inflammation supra-additively promotes the progression from prediabetes to diabetes: a prospective cohort study.Journal of global health · 2025Article
- Effect of carvacrol on diabetes-induced oxidative stress, fibrosis and apoptosis in testicular tissues of adult rats.Physiological research · 2025Article
- Association of inflammatory score with all-cause and cardiovascular mortality in patients with metabolic syndrome: NHANES longitudinal cohort study.Frontiers in immunology · 2024Article
- A prospective hospital-based study on C-reactive protein as a response predictor of antidepressant treatment in drug naïve patients with major depressive disorder.Indian journal of psychiatry · 2023Article
- Brown adipose tissue is not associated with cachexia or increased mortality in a retrospective study of patients with cancer.American journal of physiology. Endocrinology and metabolism · 2023Article
- Inflammation, dysregulated iron metabolism, and cardiovascular disease.Frontiers in aging · 2023Review
- Article
- The relationship between C-Reactive protein and mortality in adults with diabetes: Influences of demographic characteristics, lifestyle behaviors, and medications.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2022Article
- Association of lung function with the risk of cardiovascular diseases and all-cause mortality in patients with diabetes: Results from NHANES III 1988-1994.Frontiers in cardiovascular medicine · 2022Article
- Role of inflammation in diabetic cardiomyopathy.Therapeutic advances in endocrinology and metabolism · 2022Review
- Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes.Cardiovascular diabetology · 2021Article
- Highlights from the 2019 International Aspirin Foundation Scientific Conference, Rome, 28 June 2019: benefits and risks of antithrombotic therapy for cardiovascular disease prevention.Ecancermedicalscience · 2020Article
- Exercise and Type 1 Diabetes.Advances in experimental medicine and biology · 2020Review
- Comparison of cystatin C- and creatinine-based estimated glomerular filtration rates for predicting all-cause mortality in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry.Clinical and experimental nephrology · 2017Article
- The Predictive Role of Tooth Extractions, Oral Infections, and hs-C-Reactive Protein for Mortality in Individuals with and without Diabetes: A Prospective Cohort Study of a 12 1/2-Year Follow-Up.Journal of diabetes research · 2017Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine to what extent plasma C-reactive protein (CRP) values influence 5-year all-cause and cardiovascular mortality in type 2 diabetic individuals, independently of albumin excretion rate (AER) and other cardiovascular risk factors, and its incremental usefulness for predicting individual risk of mortality. RESEARCH DESIGN AND
methodsMeasurements of CRP were performed in 2,381 of 3,249 (73.3%) subjects as part of the population-based Casale Monferrato Study. Its association with 5-year all-cause and cardiovascular mortality was assessed with multivariate Cox proportional hazards modeling. The C statistic and measures of calibration and global fit were also assessed.
resultsResults are based on 496 deaths in 11.717 person-years of observations (median follow-up 5.4 years). With respect to subjects with CRP < or =3 mg/l, those with higher values had an adjusted hazard ratio (HR) of 1.51 (95% CI 1.18-1.92) for all-cause mortality and 1.44 (0.99-2.08) for cardiovascular mortality. In normoalbuminuric subjects, respective HRs of CRP were 1.56 (1.13-2.15) and 1.65 (1.00-2.74), AER being neither a modifier nor a confounder of CRP association. In analysis limited to diabetic subjects without cardiovascular disease (CVD), adjusted HRs were 1.67 (1.24-2.24) for all-cause mortality and 1.36 (0.83-2.24) for cardiovascular mortality. The improvement in individual risk assessment was marginal when measured with various statistical measures of model discrimination, calibration, and global fit.
conclusionsCRP measurement is independently associated with short-term mortality risk in type 2 diabetic individuals, even in normoalbuminuric subjects and in those without a previous diagnosis of CVD. Its clinical usefulness in individual assessment of 5-year risk of mortality, however, is limited.
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