ReviewThe American journal of pathology2009
Where asthma and hypersensitivity pneumonitis meet and differ: noneosinophilic severe asthma.
Review in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Complete Blood Cell Count Parameters Predict Mortality in Patients with Hypersensitivity Pneumonitis.Diagnostics (Basel, Switzerland) · 2025Article
- Nationwide Study of the Epidemiology, Diagnosis, and Treatment of Hypersensitivity Pneumonitis in Korea.Journal of Korean medical science · 2024Article
- A comprehensive summary of disease variants implicated in metal allergy.Journal of toxicology and environmental health. Part B, Critical reviews · 2022Review
- Ginger-derived compounds exertExperimental and therapeutic medicine · 2022Article
- Evaluation of the skin-sensitizing potential of gold nanoparticles and the impact of established dermal sensitivity on the pulmonary immune response to various forms of gold.Nanotoxicology · 2020Article
- Lung parenchymal and airway changes on CT imaging following allergen challenge and bronchoalveolar lavage in atopic and asthmatic subjects.Annals of translational medicine · 2020Article
- An unusual but unmissable link between summer-type hypersensitivity pneumonitis and asthma in an old house.Respiratory medicine case reports · 2020Article
- Surface area- and mass-based comparison of fine and ultrafine nickel oxide lung toxicity and augmentation of allergic response in an ovalbumin asthma model.Inhalation toxicology · 2019Article
- Article
- Article
- Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation.Mucosal immunology · 2015Article
- Interstitial lung disease with multiple microgranulomas in chronic granulomatous disease.Journal of clinical immunology · 2014Article
- Inflammation-related effects of diesel engine exhaust particles: studies on lung cells in vitro.BioMed research international · 2013Review
- Differential regulation of inflammation and immunity in mild and severe experimental asthma.Mediators of inflammation · 2013Article
- Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.Journal of biomedical science · 2011Article
- The influence of water activity and temperature on germination, growth and sporulation of Stachybotrys chartarum strains.Mycopathologia · 2011Article
- The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling.Nature medicine · 2011Article
- Innate immunity and the pathogenicity of inhaled microbial particles.International journal of biological sciences · 2011Review
- Precarious balance: Th17 cells in host defense.Infection and immunity · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma is a type-I allergic airway disease characterized by Th(2) cells and IgE. Episodes of bronchial inflammation, eosinophilic in nature and promoting bronchoconstriction, may become chronic and lead to persistent respiratory symptoms and irreversible structural airway changes. Representative mostly of mild to moderate asthma, this clinical definition fails to account for the atypical and often more severe phenotype found in a considerable proportion of asthmatics who have increased neutrophil cell counts in the airways as a distinguishing trait. Neutrophilic inflammation is a hallmark of another type of allergic airway pathology, hypersensitivity pneumonitis. Considered as an immune counterpart of asthma, hypersensitivity pneumonitis is a prototypical type-III allergic inflammatory reaction involving the alveoli and lung interstitium, steered by Th(1) cells and IgG and, in its chronic form, accompanied by fibrosis. Although pathologically very different and commonly approached as separate disorders, as discussed in this review, clinical studies as well as data from animal models reveal undeniable parallels between both airway diseases. Danger signaling elicited by the allergenic agent or by accompanying microbial patterns emerges as critical in enabling immune sensitization and in determining the type of sensitization and ensuing allergic disease. On this basis, we propose that asthma allergens cause severe noneosinophilic asthma because of sensitization in the presence of hypersensitivity pneumonitis-promoting danger signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.