ArticleEndocrinology2009
Thyroid hormone receptor-beta is associated with coronary angiogenesis during pathological cardiac hypertrophy.
Article in Endocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- The predictive value of the FT3/FT4 ratio for the severity of coronary artery disease in patients with acute coronary syndrome.Frontiers in physiology · 2025Article
- The Role of Thyroid Diseases and their Medications in Cardiovascular Disorders: A Review of the Literature.Current cardiology reviews · 2020Review
- Thyroid hormone signaling and consequences for cardiac development.The Journal of endocrinology · 2019Review
- Bone marrow-derived cells and their conditioned medium induce microvascular repair in uremic rats by stimulation of endogenous repair mechanisms.Scientific reports · 2017Article
- Role of the Thyroid System in the Dynamic Complex Network of Cardioprotection.European cardiology · 2016Review
- Cardioprotection and thyroid hormones.Heart failure reviews · 2016Review
- Role of thyroid hormones in ventricular remodeling.Current heart failure reports · 2015Review
- In vivo selective expression of thyroid hormone receptor α1 in endothelial cells attenuates myocardial injury in experimental myocardial infarction in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor.Science signaling · 2014Article
- Low-dose T₃ replacement restores depressed cardiac T₃ levels, preserves coronary microvasculature and attenuates cardiac dysfunction in experimental diabetes mellitus.Molecular medicine (Cambridge, Mass.) · 2014Article
- Deciphering direct and indirect influence of thyroid hormone with mouse genetics.Molecular endocrinology (Baltimore, Md.) · 2014Review
- Essential role of TEA domain transcription factors in the negative regulation of the MYH 7 gene by thyroid hormone and its receptors.PloS one · 2014Article
- Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor α1.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- VDAC: old protein with new roles in diabetes.American journal of physiology. Cell physiology · 2012Article
- Thyroid hormone induces sprouting angiogenesis in adult heart of hypothyroid mice through the PDGF-Akt pathway.Journal of cellular and molecular medicine · 2012Article
- Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets.Pharmacology & therapeutics · 2012Review
- Thyroid hormone receptor-α and vascular function.American journal of physiology. Cell physiology · 2012Article
- Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats.Journal of cellular and molecular medicine · 2011Article
- New insights into the role of thyroid hormone in cardiac remodeling: time to reconsider?Heart failure reviews · 2011Review
- Signaling mechanisms in thyroid hormone-induced cardiac hypertrophy.Vascular pharmacologyReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Insufficient angiogenesis is one of the causes leading to tissue ischemia and dysfunction. In heart failure, there is increasing evidence showing decreased capillary density in the left ventricle (LV) myocardium, although the detailed mechanisms contributing to it are not clear. The goal of this study was to investigate the role of thyroid hormone receptors (TRs) in the coronary microvascular rarefaction under pathological cardiac hypertrophy. The LV from hypertrophied/failing hearts induced by ascending aortic constriction (AAC) exhibited severe microvascular rarefaction, and this phenomenon was restored by chronic T(3) administration. Coronary endothelial cells (ECs) isolated from AAC hearts expressed lower TRbeta mRNA than control ECs, and chronic T(3) administration restored TRbeta mRNA expression level in AAC hearts to the control level. Among different TR subtype-specific knockout mice, TRbeta knockout and TRalpha/TRbeta double-knockout mice both exhibited significantly less capillary density in LV compared with wild-type mice. In vitro, coronary ECs isolated from TRbeta knockout mice lacked the ability to form capillary networks. In addition, we identified that kinase insert domain protein receptor/fetal liver kinase-1 (vascular endothelial growth factor-2 receptor) was one of the angiogenic mediators controlled by T(3) administration in the AAC heart. These data suggest that TRbeta in the coronary ECs regulates capillary density during cardiac development, and down-regulation of TRbeta results in coronary microvascular rarefaction during pathological hypertrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.