ArticleJournal of bacteriology2009
The Lactobacillus plantarum ftsH gene is a novel member of the CtsR stress response regulon.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Isolation of derivatives from the food-grade probioticGut microbes · 2025Article
- Strategies to enhance stress tolerance in lactic acid bacteria across diverse stress conditions.World journal of microbiology & biotechnology · 2024Review
- Article
- Investigation of CRISPR-Independent Phage Resistance Mechanisms Reveals a Role for FtsH in Phage Adsorption to Streptococcus thermophilus.Journal of bacteriology · 2023Article
- Homologous genes shared between probiotics and pathogens affect the adhesion of probiotics and exclusion of pathogens in the gut mucus of shrimp.Frontiers in microbiology · 2023Article
- Genome-wide identification and expression analysis of the ftsH protein family and its response to abiotic stress in Nicotiana tabacum L.BMC genomics · 2022Article
- Cell wall homeostasis in lactic acid bacteria: threats and defences.FEMS microbiology reviews · 2020Review
- Characterization of a stress tolerance-defective mutant of Lactobacillus rhamnosus LRB.Molecular oral microbiology · 2019Article
- The Phenotypic Analysis ofFrontiers in microbiology · 2019Article
- Response ofFrontiers in microbiology · 2019Article
- Chlorophyll fluorescence analysis revealed essential roles of FtsH11 protease in regulation of the adaptive responses of photosynthetic systems to high temperature.BMC plant biology · 2018Article
- Enhancing water stress tolerance improves fitness in biological control strains of Lactobacillus plantarum in plant environments.PloS one · 2018Article
- Role ofBioMed research international · 2018Article
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- Lactobacillus plantarum WCFS1 and its host interaction: a dozen years after the genome.Microbial biotechnology · 2016Review
- The impact of heterologous catalase expression and superoxide dismutase overexpression on enhancing the oxidative resistance in Lactobacillus casei.Journal of industrial microbiology & biotechnology · 2016Article
- Article
- Functional Starters for Functional Yogurt.Foods (Basel, Switzerland) · 2015Article
- Transcriptome signatures of class I and III stress response deregulation in Lactobacillus plantarum reveal pleiotropic adaptation.Microbial cell factories · 2013Article
- ClpL is required for folding of CtsR in Streptococcus mutans.Journal of bacteriology · 2013Article
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
FtsH proteins have dual chaperone-protease activities and are involved in protein quality control under stress conditions. Although the functional role of FtsH proteins has been clearly established, the regulatory mechanisms controlling ftsH expression in gram-positive bacteria remain largely unknown. Here we show that ftsH of Lactobacillus plantarum WCFS1 is transiently induced at the transcriptional level upon a temperature upshift. In addition, disruption of ftsH negatively affected the growth of L. plantarum at high temperatures. Sequence analysis and mapping of the ftsH transcriptional start site revealed a potential operator sequence for the CtsR repressor, partially overlapping the -35 sequence of the ftsH promoter. In order to verify whether CtsR is able to recognize and bind the ftsH promoter, CtsR proteins of Bacillus subtilis and L. plantarum were overproduced, purified, and used in DNA binding assays. CtsR from both species bound specifically to the ftsH promoter, generating a single protein-DNA complex, suggesting that CtsR may control the expression of L. plantarum ftsH. In order to confirm this hypothesis, a DeltactsR mutant strain of L. plantarum was generated. Expression of ftsH in the DeltactsR mutant strain was strongly upregulated, indicating that ftsH of L. plantarum is negatively controlled by CtsR. This is the first example of an ftsH gene controlled by the CtsR repressor, and the first of the low-G+C gram-positive bacteria where the regulatory mechanism has been identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.