ArticleJournal of bacteriology2009
Regulation and activity of a zinc uptake regulator, Zur, in Corynebacterium diphtheriae.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Protein Architecture and Composition in Mycobacterium tuberculosis.Advances in experimental medicine and biology · 2026Review
- Article
- Identification and characterization of zinc importers inJournal of bacteriology · 2024Article
- Virulence regulation of ZnFrontiers in veterinary science · 2023Article
- Article
- Bacillus subtilis Regulators MntR and Zur Participate in Redox Cycling, Antibiotic Sensitivity, and Cell Wall Plasticity.Journal of bacteriology · 2020Article
- Article
- Genomic Insights Into Plant-Growth-Promoting Potentialities of the GenusFrontiers in microbiology · 2019Article
- Bacterial zinc uptake regulator proteins and their regulons.Biochemical Society transactions · 2018Review
- Iron and Zinc Regulate Expression of a Putative ABC Metal Transporter in Corynebacterium diphtheriae.Journal of bacteriology · 2018Article
- The Components of the Unique Zur Regulon of Cupriavidus metallidurans Mediate Cytoplasmic Zinc Handling.Journal of bacteriology · 2017Article
- Insight of GenusFrontiers in microbiology · 2017Review
- Zinc-Dependent Transcriptional Regulation inFrontiers in microbiology · 2017Article
- Agrobacterium tumefaciens Zur Regulates the High-Affinity Zinc Uptake System TroCBA and the Putative Metal Chaperone YciC, along with ZinT and ZnuABC, for Survival under Zinc-Limiting Conditions.Applied and environmental microbiology · 2016Article
- The ZupT transporter plays an important role in zinc homeostasis and contributes to Salmonella enterica virulence.Metallomics : integrated biometal science · 2014Article
- The proteome of copper, iron, zinc, and manganese micronutrient deficiency in Chlamydomonas reinhardtii.Molecular & cellular proteomics : MCP · 2013Article
- Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria.Frontiers in cellular and infection microbiology · 2013Review
- The transcriptional regulator Np20 is the zinc uptake regulator in Pseudomonas aeruginosa.PloS one · 2013Article
- Metalloregulation of Gram-positive pathogen physiology.Current opinion in microbiology · 2012Review
- ROS-Mediated Signalling in Bacteria: Zinc-Containing Cys-X-X-Cys Redox Centres and Iron-Based Oxidative Stress.Journal of signal transduction · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Regulation of metal ion homeostasis is essential to bacterial cell survival, and in most species it is controlled by metal-dependent transcriptional regulators. In this study, we describe a Corynebacterium diphtheriae ferric uptake regulator-family protein, Zur, that controls expression of genes involved in zinc uptake. By measuring promoter activities and mRNA levels, we demonstrate that Zur represses transcription of three genes (zrg, cmrA, and troA) in zinc-replete conditions. All three of these genes have similarity to genes involved in zinc uptake. Transcription of zrg and cmrA was also shown to be regulated in response to iron and manganese, respectively, by mechanisms that are independent of Zur. We demonstrate that the activity of the zur promoter is slightly decreased under low zinc conditions in a process that is dependent on Zur itself. This regulation of zur transcription is distinctive and has not yet been described for any other zur. An adjacent gene, predicted to encode a metal-dependent transcriptional regulator in the ArsR/SmtB family, is transcribed from a separate promoter whose activity is unaffected by Zur. A C. diphtheriae zur mutant was more sensitive to peroxide stress, which suggests that zur has a role in protecting the bacterium from oxidative damage. Our studies provide the first evidence of a zinc specific transcriptional regulator in C. diphtheriae and give new insights into the intricate regulatory network responsible for regulating metal ion concentrations in this toxigenic human pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.