ArticleProceedings of the National Academy of Sciences of the United States of America2008
Computation of mutual fitness by competing bacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 63 citations in OpenAlex.
- High-throughput bacterial aggregation analysis in droplets.Scientific reports · 2025Article
- Measuring single-cell susceptibility to antibiotics within monoclonal bacterial populations.PloS one · 2024Article
- Emergence of ResistantFrontiers in microbiology · 2022Article
- Real-time tracking of bacterial membrane vesicles reveals enhanced membrane traffic upon antibiotic exposure.Science advances · 2021Article
- Bacteria-in-paper, a versatile platform to study bacterial ecology.Ecology letters · 2019Article
- Interactions mediated by a public good transiently increase cooperativity in growing Pseudomonas putida metapopulations.Scientific reports · 2018Article
- Application of Microfluidics in Experimental Ecology: The Importance of Being Spatial.Frontiers in microbiology · 2018Review
- Defector clustering is linked to cooperation in a pathogenic bacterium.Proceedings. Biological sciences · 2017Article
- Microbial competition in porous environments can select against rapid biofilm growth.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Microfluidic Studies of Biofilm Formation in Dynamic Environments.Journal of bacteriology · 2016Review
- Density-dependent adaptive resistance allows swimming bacteria to colonize an antibiotic gradient.The ISME journal · 2016Article
- Fabrication of nanoporous membranes for tuning microbial interactions and biochemical reactions.Journal of vacuum science and technology. B, Nanotechnology & microelectronics : materials, processing, measurement, & phenomena : JVST B · 2015Article
- The idiosyncrasy of spatial structure in bacterial competition.BMC research notes · 2015Article
- Fast, high-throughput measurement of collective behaviour in a bacterial population.Journal of the Royal Society, Interface · 2014Article
- You cannot tell a book by looking at the cover: Cryptic complexity in bacterial evolution.Biomicrofluidics · 2014Article
- Bacteria and game theory: the rise and fall of cooperation in spatially heterogeneous environments.Interface focus · 2014Review
- The effects of chemical interactions and culture history on the colonization of structured habitats by competing bacterial populations.BMC microbiology · 2014Article
- Microfluidics expanding the frontiers of microbial ecology.Annual review of biophysics · 2014Review
- Microfluidic picoliter bioreactor for microbial single-cell analysis: fabrication, system setup, and operation.Journal of visualized experiments : JoVE · 2013Article
- High-throughput particle manipulation by hydrodynamic, electrokinetic, and dielectrophoretic effects in an integrated microfluidic chip.Biomicrofluidics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Competing populations in shared spaces with nonrenewable resources do not necessarily wage a battle for dominance at the cost of extinction of the less-fit strain if there are fitness advantages to the presence of the other strain. We report on the use of nanofabricated habitat landscapes to study the population dynamics of competing wild type and a growth advantage in stationary phase (GASP) mutant strains of Escherichia coli in a sealed and heterogeneous nutrient environment. Although GASP mutants are competitors with wild-type bacteria, we find that the 2 strains cooperate to maximize fitness (long-term total productivity) via spatial segregation: despite their very close genomic kinship, wild-type populations associate with wild-type populations and GASP populations with GASP populations. Thus, wild-type and GASP strains avoid each other locally, yet fitness is enhanced for both strains globally. This computation of fitness enhancement emerges from the local interaction among cells but maximizes global densities. At present we do not understand how fluctuations in both spatial and temporal dimensions lead to the emergent computation and how multilevel aggregates produce this collective adaptation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.