ArticleProceedings of the National Academy of Sciences of the United States of America2008
Memory T-lymphocyte survival does not require T-cell receptor expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Sialic acids on T cells are crucial for their maintenance and survival.Frontiers in immunology · 2024Article
- Acute effects of FLT3L treatment on T cells in intact mice.Scientific reports · 2022Article
- Interplay of Inflammatory, Antigen and Tissue-Derived Signals in the Development of Resident CD8 Memory T Cells.Frontiers in immunology · 2021Review
- Tissue-specific functions of invariant natural killer T cells.Nature reviews. Immunology · 2018Review
- TCR stimulation strength is inversely associated with establishment of functional brain-resident memory CD8 T cells during persistent viral infection.PLoS pathogens · 2017Article
- Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels.eLife · 2017Article
- The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.Nature immunology · 2014Review
- Influence of time and number of antigen encounters on memory CD8 T cell development.Immunologic research · 2014Review
- Cutting edge: Self-antigen controls the balance between effector and regulatory T cells in peripheral tissues.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Early Decision: Effector and Effector Memory T Cell Differentiation in Chronic Infection.Current immunology reviews · 2013Article
- Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo.Immunology · 2013Article
- The requirement of linker for activation of T cells in the primary and memory responses of CD8 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Hoxb4 overexpression in CD4 memory phenotype T cells increases the central memory population upon homeostatic proliferation.PloS one · 2013Article
- Regulating the immune system via IL-15 transpresentation.Cytokine · 2012Review
- Murine superficial lymph node surgery.Journal of visualized experiments : JoVE · 2012Article
- Homeostatic maintenance of T cells and natural killer cells.Cellular and molecular life sciences : CMLS · 2012Review
- Division-linked generation of death-intermediates regulates the numerical stability of memory CD8 T cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory.European journal of immunology · 2011Article
- Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells.PLoS biology · 2011Article
- Immunologic considerations for generating memory CD8 T cells through vaccination.Cellular microbiology · 2011Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The factors controlling memory T (Tm)-cell longevity are still poorly defined, and their identification is pivotal to the design of a vaccine conferring long-term protection against infection. Tm cells have the ability to survive in the absence of the T-cell receptor (TCR)-MHC interaction. This does not exclude a possible role for TCR-intrinsic ligand-independent constitutive signaling in Tm-cell homeostasis. Using a unique TCR tetracycline-inducible expression system, we show that the ablation of TCR expression, which abrogates any possible signaling via the TCR, did not influence the survival and self-renewal of antigen-specific CD8(+) Tm cells even when they have to compete with endogenous T cells for survival factors. Moreover, CD8(+) Tm-cell functionality was not altered even on prolonged maintenance in the absence of TCR-MHC interactions. Furthermore, our results show that a subset of CD4(+) Tm cells can survive in the absence of TCR expression in nonlymphopenic hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.