ArticleThe Journal of biological chemistry2009
Retinoschisin, a new binding partner for L-type voltage-gated calcium channels in the retina.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 61 citations in OpenAlex.
- Comprehensive analysis of RS1 gene mutations and clinical manifestations in nine unrelated X-linked retinoschisis (XLRS) Chinese families.BMC ophthalmology · 2026Article
- The D126G mutation contributes to the early-onset X-linked juvenile retinoschisis.Scientific reports · 2025Article
- Aland Island Eye Disease with Retinoschisis in the Clinical Spectrum ofInternational journal of molecular sciences · 2024Article
- Diurnal functional and anatomical changes in X-linked retinoschisis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Retinoschisin and novel Na/K-ATPase interaction partners Kv2.1 and Kv8.2 define a growing protein complex at the inner segments of mammalian photoreceptors.Cellular and molecular life sciences : CMLS · 2022Article
- Development and maintenance of vision's first synapse.Developmental biology · 2021Review
- Retinoschisis and Norrie disease: a missing link.BMC research notes · 2021Article
- Expression and Localization of Kcne2 in the Vertebrate Retina.Investigative ophthalmology & visual science · 2020Article
- Mouse models of X-linked juvenile retinoschisis have an early onset phenotype, the severity of which varies with genotype.Human molecular genetics · 2019Article
- Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina.The Journal of cell biology · 2019Article
- Article
- Diurnal variations of foveoschisis by optical coherence tomography in patients with RS1 X-linked juvenile retinoschisis.Ophthalmic genetics · 2018Article
- Understanding variable disease severity in X-linked retinoschisis: Does RS1 secretory mechanism determine disease severity?PloS one · 2018Article
- The Contribution of L-Type CaFrontiers in molecular neuroscience · 2017Article
- Retinoschisin Facilitates the Function of L-Type Voltage-Gated Calcium Channels.Frontiers in cellular neuroscience · 2017Article
- Structural analysis of X-linked retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function.Human molecular genetics · 2016Article
- Paired octamer rings of retinoschisin suggest a junctional model for cell-cell adhesion in the retina.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Differentiation of murine models of "negative ERG" by single and repetitive light stimuli.Documenta ophthalmologica. Advances in ophthalmology · 2016Article
- Cog-Wheel Octameric Structure of RS1, the Discoidin Domain Containing Retinal Protein Associated with X-Linked Retinoschisis.PloS one · 2016Article
- Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer.The Journal of clinical investigation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
The L-type voltage-gated calcium channels (L-VGCCs) are activated under high depolarization voltages. They are vital for diverse biological events, including cell excitability, differentiation, and synaptic transmission. In retinal photoreceptors, L-VGCCs are responsible for neurotransmitter release and are under circadian influences. However, the mechanism of L-VGCC regulation in photoreceptors is not fully understood. Here, we show that retinoschisin, a highly conserved extracellular protein, interacts with the L-VGCCalpha1D subunit and regulates its activities in a circadian manner. Mutations in the gene encoding retinoschisin (RS1) cause retinal disorganization that leads to early onset of macular degeneration. Since ion channel activities can be modulated through interactions with extracellular proteins, disruption of these interactions can alter physiology and be the root cause of disease states. Co-immunoprecipitation and mammalian two-hybrid assays showed that retinoschisin and the N-terminal fragment of the L-VGCCalpha1 subunit physically interacted with one another. The expression and secretion of retinoschisin are under circadian regulation with a peak at night and nadir during the day. Inhibition of L-type VGCCs decreased membrane-bound retinoschisin at night. Overexpression of a missense RS1 mutant gene, R141G, into chicken cone photoreceptors caused a decrease of L-type VGCC currents at night. Our findings demonstrate a novel bidirectional relationship between an ion channel and an extracellular protein; L-type VGCCs regulate the circadian rhythm of retinoschisin secretion, whereas secreted retinoschisin feeds back to regulate L-type VGCCs. Therefore, physical interactions between L-VGCCalpha1 subunits and retinoschisin play an important role in the membrane retention of L-VGCCalpha1 subunits and photoreceptor-bipolar synaptic transmission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.