Evidence map›Paper›PMID 19073872›Full record

ArticleJournal of clinical microbiology2009

Diagnosis of human immunodeficiency virus type 1 infection in infants by use of dried blood spots and an ultrasensitive p24 antigen assay.

Ada Cachafeiro, Gayle G Sherman, Annette H Sohn, Consuelo Beck-Sague, Susan A Fiscus

Abstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. An overview of the clinical use of filter paper in the diagnosis of tropical diseases.The American journal of tropical medicine and hygiene · 2014
    Review
  5. Point of Care Technologies for HIV.AIDS research and treatment · 2014
    Review
  6. Article
  7. Review
  8. Analysis of the optimal cut-point for HIV-p24 antigen testing to diagnose HIV infection in HIV-exposed children from resource-constrained settings.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2011
    Article
  9. Using a simplified human immunodeficiency virus type 1 p24 antigen assay to diagnose pediatric HIV-infection in Malawi.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2010
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ada CachafeiroDepartment Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7290, USA.
Gayle G Sherman
Annette H Sohn
Consuelo Beck-Sague
Susan A Fiscus

Funding

International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) GroupU01AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI JACKSON, J BROOKS · 2006 to 2010
$109.7M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
p24 Antigen and Alternative Markers in Infants, VietnamK23HD047166 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOHN, ANNETTE H · 2004 to 2008
$500k
NCCDPHP CDC HHS SIP 26-04 U48-DP000059-01NCCDPHP CDC HHS U48 DP000059NIAID NIH HHS P30 AI050410NIAID NIH HHS P30AI50410NIAID NIH HHS U01 AI068632NIAID NIH HHS U01AI068632NICHD NIH HHS K23 HD047166NICHD NIH HHS K23HD047166PHS HHS SIP 13-01 U48-CCU409660-09
6 · The paper itself

Abstract

We tested 617 dried blood spots (DBS) from human immunodeficiency virus-exposed infants from five countries using an ultrasensitive p24 antigen assay (Up24). The sensitivity was 94.4% (67/71) and the specificity was 100% (431/431) for infants with DBS specimens <or=20 months old; DBS older than 30 months demonstrated only 72.2% sensitivity (39/54) (P < 0.001) but displayed 100% specificity (61/61).

Indexed as

DesiccationBloodHIV-1HIV Core Protein p24HIV InfectionsHumansInfantInfant, NewbornSensitivity and SpecificitySpecimen HandlingHIV Core Protein p24

Identifiers

PMID19073872
PMCPMC2643698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.