ArticleCerebral cortex (New York, N.Y. : 1991)2009
Performance effects of nicotine during selective attention, divided attention, and simple stimulus detection: an fMRI study.
Article in Cerebral cortex (New York, N.Y. : 1991), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Structural and functional brain recovery in individuals with substance use disorders during abstinence: A review of longitudinal neuroimaging studies.Drug and alcohol dependence · 2022Pooled it
- Neurobiological impact of nicotinic acetylcholine receptor agonists: an activation likelihood estimation meta-analysis of pharmacologic neuroimaging studies.Biological psychiatry · 2015Pooled it
- Neural bases of pharmacological treatment of nicotine dependence - insights from functional brain imaging: a systematic review.CNS drugs · 2013Pooled it
- Meta-analysis of the acute effects of nicotine and smoking on human performance.Psychopharmacology · 2010Pooled it
- Short-term nicotine deprivation alters dorsal anterior cingulate glutamate concentration and concomitant cingulate-cortical functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Transcranial Direct Current Stimulation Applied to the Dorsolateral and Ventromedial Prefrontal Cortices in Smokers Modifies Cognitive Circuits Implicated in the Nicotine Withdrawal Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Trial
- Neuronal effects of nicotine during auditory selective attention.Psychopharmacology · 2015Trial
- Effects of nicotine on social cognition, social competence and self-reported stress in schizophrenia patients and healthy controls.European archives of psychiatry and clinical neuroscience · 2013Trial
- Human brain functional network changes associated with enhanced and impaired attentional task performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Effects of acute nicotine on auditory change-related cortical responses.Psychopharmacology · 2012Trial
- Prompt but inefficient: nicotine differentially modulates discrete components of attention.Psychopharmacology · 2011Trial
- The effects of nicotine replacement on cognitive brain activity during smoking withdrawal studied with simultaneous fMRI/EEG.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Trial
- Direction and magnitude of nicotine effects on the fMRI BOLD response are related to nicotine effects on behavioral performance.Psychopharmacology · 2011Trial
- Changes in distinct brain systems identified with fMRI during smoking cessation treatment with varenicline: a review.Psychopharmacology · 2024Review
- Cholinergic modulation of sensory perception and plasticity.Neuroscience and biobehavioral reviews · 2023Review
- Nicotinic receptor modulation of the default mode network.Psychopharmacology · 2021Article
- Neurochemistry of Visual Attention.Frontiers in neuroscience · 2021Review
- Nicotine dependence (trait) and acute nicotinic stimulation (state) modulate attention but not inhibitory control: converging fMRI evidence from Go-Nogo and Flanker tasks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Combining Multiple Resting-State fMRI Features during Classification: Optimized Frameworks and Their Application to Nicotine Addiction.Frontiers in human neuroscience · 2017Article
- Resting-state functional connectivity and nicotine addiction: prospects for biomarker development.Annals of the New York Academy of Sciences · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Attention-enhancing effects of nicotine appear to depend on the nature of the attentional function. Underlying neuroanatomical mechanisms, too, may vary depending on the function modulated. This functional magnetic resonance imaging study recorded blood oxygen level-dependent (BOLD) activity in minimally deprived smokers during tasks of simple stimulus detection, selective attention, or divided attention after single-blind application of a transdermal nicotine (21 mg) or placebo patch. Smokers' performance in the placebo condition was unimpaired as compared with matched nonsmokers. Nicotine reduced reaction time (RT) in the stimulus detection and selective attention but not divided attention condition. Across all task conditions, nicotine reduced activation in frontal, temporal, thalamic, and visual regions and enhanced deactivation in so-called "default" regions. Thalamic effects correlated with RT reduction selectively during stimulus detection. An interaction with task condition was observed in middle and superior frontal gyri, where nicotine reduced activation only during stimulus detection. A visuomotor control experiment provided evidence against nonspecific effects of nicotine. In conclusion, although prefrontal activity partly displayed differential modulation by nicotine, most BOLD effects were identical across tasks, despite differential performance effects, suggesting that common neuronal mechanisms can selectively benefit different attentional functions. Overall, the effects of nicotine may be explained by increased functional efficiency and downregulated task-independent "default" functions.
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Registered trials
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