ReviewSeminars in cell & developmental biology2009
Presenilin: RIP and beyond.
Review in Seminars in cell & developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 84 citations in OpenAlex.
- NOTCH pathway inactivation promotes bladder cancer progression.The Journal of clinical investigation · 2015Trial
- Editorial: DNA methylation: The aging clock.Frontiers in cell and developmental biology · 2023Article
- The critical role of γ-secretase and its inhibitors in cancer and cancer therapeutics.International journal of biological sciences · 2023Review
- Promoter Hypomethylation of TGFBR3 as a Risk Factor of Alzheimer's Disease: An Integrated Epigenomic-Transcriptomic Analysis.Frontiers in cell and developmental biology · 2021Article
- CpG and non-CpG Presenilin1 methylation pattern in course of neurodevelopment and neurodegeneration is associated with gene expression in human and murine brain.Epigenetics · 2020Article
- Targeting p75 neurotrophin receptors ameliorates spinal cord injury-induced detrusor sphincter dyssynergia in mice.Neurourology and urodynamics · 2018Article
- Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Effects of grape seed proanthocyanidin on Alzheimer's diseaseExperimental and therapeutic medicine · 2016Article
- Fibroblast growth factor rescues brain endothelial cells lacking presenilin 1 from apoptotic cell death following serum starvation.Scientific reports · 2016Article
- Role of Notch signaling in regulating innate immunity and inflammation in health and disease.Protein & cell · 2016Review
- Calcium signaling in trypanosomatid parasites.Cell calcium · 2015Review
- EpCAM and the biology of hepatic stem/progenitor cells.American journal of physiology. Gastrointestinal and liver physiology · 2015Review
- Effects of aluminium on β-amyloid (1-42) and secretases (APP-cleaving enzymes) in rat brain.Neurochemical research · 2014Article
- Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP.Aging cell · 2014Article
- Different functions of HOPS isoforms in the cell: HOPS shuttling isoform is determined by RIP cleavage system.Cell cycle (Georgetown, Tex.) · 2014Article
- The involvement of microRNAs in neurodegenerative diseases.Frontiers in cellular neuroscience · 2013Review
- Presenilin 2 influences miR146 level and activity in microglia.Journal of neurochemistry · 2013Article
- Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells.PloS one · 2013Article
- Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells.BMC biochemistry · 2012Article
- Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK.Cancer cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Over the years the presenilins (PSENs), a family of multi-transmembrane domain proteins, have been ascribed a number of diverse potential functions. Recent in vivo evidence has supported the existence of PSEN functions beyond its well-established role in regulated intramembrane proteolysis. In this review, we will briefly discuss the ability of PSEN to modulate cellular signaling pathways through gamma-secretase cleavage of transmembrane proteins. Additionally, we will critically examine the proposed roles of PSEN in the regulation of beta-catenin function, protein trafficking, calcium regulation, and apoptosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.