ArticleBehavioural brain research2009
Modeling operant behavior in the Parkinsonian rat.
Article in Behavioural brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Trial
- Adolescent methylmercury exposure alters short-term remembering, but not sustained attention, in male Long-Evans rats.Neurotoxicology · 2020Article
- d-Amphetamine and methylmercury exposure during adolescence alters sensitivity to monoamine uptake inhibitors in adult mice.Neurotoxicology · 2019Article
- Reinforcement omission effects in rats with bilateral lesions in the substantia nigra pars compacta and ventral tegmental area.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence.Brain sciences · 2018Article
- The Mechanisms of Traditional Chinese Medicine Underlying the Prevention and Treatment of Parkinson's Disease.Frontiers in pharmacology · 2017Review
- Adolescent methylmercury exposure affects choice and delay discounting in mice.Neurotoxicology · 2016Article
- Revisiting the effect of nicotine on interval timing.Behavioural brain research · 2015Article
- A generalized matching law analysis of cocaine vs. food choice in rhesus monkeys: effects of candidate 'agonist-based' medications on sensitivity to reinforcement.Drug and alcohol dependence · 2015Article
- A quantitative analysis of the effects of qualitatively different reinforcers on fixed ratio responding in inbred strains of mice.Neurobiology of learning and memory · 2013Article
- Model-based and model-free mechanisms of human motor learning.Advances in experimental medicine and biology · 2013Article
- The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease.Journal of physiology and biochemistry · 2012Article
- The isolation of motivational, motoric, and schedule effects on operant performance: a modeling approach.Journal of the experimental analysis of behavior · 2011Article
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8 authors.
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Abstract
Mathematical principles of reinforcement (MPR; Killeen, 1994) is a quantitative model of operant behavior that contains three parameters representing motor capacity (delta), motivation (a), and short term memory (lambda). The present study applied MPR to characterize the effects of bilateral infusions of 6-OHDA into the substantia nigra pars compacta in the rat, a model of Parkinson's disease. Rats were trained to lever press under a 5-component fixed-ratio (5, 15, 30, 60, and 100) schedule of food reinforcement. Rats were tested for 15 days prior to dopamine lesions and again for 15 days post-lesion. To characterize functional loss relative to lesion size, rats were grouped according to the extent and the degree of lateralization of their dopamine loss. Response rates decreased as a function of dopamine depletion, primarily at intermediate ratios. MPR accounted for 98% of variance in pre- and post-lesion response rates. Consistent with reported disruptions in motor behavior induced by dopaminergic lesions, estimates of delta increased when dopamine was severely depleted. There was no support for different estimates of a based on pre- and post-lesion performance of any lesion group, suggesting that dopamine loss has negligible effects on incentive motivation. The present study demonstrates the usefulness of combining operant techniques with a theoretical model to better understand the effects of a neurochemical manipulation.
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