ArticleDevelopmental biology2009
The human placenta is a hematopoietic organ during the embryonic and fetal periods of development.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Pooled it
- Current Status of Biomedical Products for Gene and Cell Therapy of Recessive Dystrophic Epidermolysis Bullosa.International journal of molecular sciences · 2024Review
- The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies.Stem cell reviews and reports · 2021Review
- Efficacy of Human Placental-Derived Stem Cells in Collagen VII Knockout (Recessive Dystrophic Epidermolysis Bullosa) Animal Model.Stem cells translational medicine · 2018Article
- Cellular kinetics of perivascular MSC precursors.Stem cells international · 2013Review
- Multipotent stromal stem cells from human placenta demonstrate high therapeutic potential.Stem cells translational medicine · 2012Article
- Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.Developmental cell · 2012Article
- Hematopoietic stem cell development, niches, and signaling pathways.Bone marrow research · 2012Article
- Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region.The Journal of experimental medicine · 2011Article
- Human placenta and chorion: potential additional sources of hematopoietic stem cells for transplantation.Transfusion · 2011Article
- Aberrant growth and pattern formation in Peromyscus hybrid placental development.Biology of reproduction · 2010Article
- The first trimester human placenta is a site for terminal maturation of primitive erythroid cells.Blood · 2010Article
- Placenta as a source of hematopoietic stem cells.Trends in molecular medicine · 2010Review
- Placenta as a newly identified source of hematopoietic stem cells.Current opinion in hematology · 2010Review
- Hematopoietic stem cell development in the placenta.The International journal of developmental biology · 2010Review
- Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development.Cell stem cell · 2009Article
Corrections and comments
- Retraction · 2015-03-24Duplication of Data · Duplication of/in Image ·
- Retracted
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We studied the potential role of the human placenta as a hematopoietic organ during embryonic and fetal development. Placental samples contained two cell populations-CD34(++)CD45(low) and CD34(+)CD45(low)-that were found in chorionic villi and in the chorioamniotic membrane. CD34(++)CD45(low) cells express many cell surface antigens found on multipotent primitive hematopoietic progenitors and hematopoietic stem cells. CD34(++)CD45(low) cells contained colony-forming units culture (CFU-C) with myeloid and erythroid potential in clonogenic in vitro assays, and they generated CD56(+) natural killer cells and CD19(+)CD20(+)sIgM(+) B cells in polyclonal liquid cultures. CD34(+)CD45(low) cells mostly comprised erythroid- and myeloid-committed progenitors, while CD34(-) cells lacked CFU-C. The placenta-derived precursors were fetal in origin, as demonstrated by FISH using repeat-sequence chromosome-specific probes for X and Y. The number of CD34(++)CD45(low) cells increased with gestational age, but their density (cells per gram of tissue) peaked at 5-8 wk, decreasing more than sevenfold at the onset of the fetal phase (9 wk of gestation). In addition to multipotent progenitors, the placenta contained myeloid- and erythroid-committed progenitors indicative of active in situ hematopoiesis. These data suggest that the human placenta is an important hematopoietic organ, raising the possibility of banking placental hematopoietic stem cells along with cord blood for transplantation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.