ArticleArchives of insect biochemistry and physiology2009
Molecular analysis of juvenile hormone analog action in controlling the metamorphosis of the red flour beetle, Tribolium castaneum.
Article in Archives of insect biochemistry and physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 53 citations in OpenAlex.
- Juvenile hormone receptor Methoprene tolerant: Functions and applications.Vitamins and hormones · 2023Article
- Stage-specific action of juvenile hormone analogs.Journal of pesticide science · 2021Article
- Biotic stress triggered small RNA and RNAi defense response in plants.Molecular biology reports · 2020Review
- Identification of target genes for RNAi-mediated control of the Twospotted Spider Mite.Scientific reports · 2018Article
- Rapid juvenile hormone downregulation in subordinate wasp queens facilitates stable cooperation.Proceedings. Biological sciences · 2018Article
- Multiple functions of CREB-binding protein during postembryonic development: identification of target genes.BMC genomics · 2017Article
- Article
- Emerging strategies for RNA interference (RNAi) applications in insects.Bioengineered · 2015Review
- Endocrine regulation of predator-induced phenotypic plasticity.Oecologia · 2014Article
- Microarray Analysis of the Juvenile Hormone Response in Larval Integument of the Silkworm, Bombyx mori.International journal of genomics · 2014Article
- Advertised quality, caste and food availability influence the survival cost of juvenile hormone in paper wasps.Proceedings. Biological sciences · 2010Article
- Mode of action of methoprene in affecting female reproduction in the African malaria mosquito, Anopheles gambiae.Pest management science · 2010Article
- Juvenile hormone regulation of male accessory gland activity in the red flour beetle, Tribolium castaneum.Mechanisms of development · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
The juvenile hormone analogs (JHA) are known to disrupt insect development but the molecular mechanisms of their action have been studied only in a few model insects belonging to orders Diptera and Lepidoptera. Here, we investigated the mechanisms of JHA action in red flour beetle, Tribolium castaneum, belonging to the order Coleoptera. Application of JHA during penultimate and final instar larval stages blocked larval-pupal metamorphosis and induced supernumerary larval molts. When compared to the control insects undergoing larval-pupal molt, down-regulation of expression of transcription factor, Broad, and up-regulation of other genes involved in 20-hydroxyecdysone (20E) action (FTZ-F1, E74) were observed in JHA-treated larvae undergoing supernumerary larval molts. The presence of JHA during the final instar larval stage blocked the midgut remodeling wherein programmed cell death (PCD) of larval cells and proliferation and differentiation of imaginal cells to pupal gut epithelium were impaired. The comparative analysis of 20E-induced gene expression in the midguts of JHA-treated and control insects revealed that JHA suppressed the expression of EcRA, EcRB, Broad, E74, E75A, and E75B, resulting in a block in PCD as well as proliferation and differentiation of imaginal cells.
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