ArticleMolecular nutrition & food research2009
Inorganic arsenic as a developmental toxicant: in utero exposure and alterations in the developing rat lungs.
Article in Molecular nutrition & food research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Serum intracellular adhesion molecule-1 and interleukin-8 as predictors of pulmonary impairment among workers in secondary copper smelters.International archives of occupational and environmental health · 2022Article
- Arsenic represses airway epithelial mucin expression by affecting retinoic acid signaling pathway.Toxicology and applied pharmacology · 2020Article
- Early life inhalation exposure to mine tailings dust affects lung development.Toxicology and applied pharmacology · 2019Article
- Impact of prenatal arsenic exposure on chronic adult diseases.Systems biology in reproductive medicine · 2018Review
- Arsenic and Immune Response to Infection During Pregnancy and Early Life.Current environmental health reports · 2017Review
- Arsenite Effects on Mitochondrial Bioenergetics in Human and Mouse Primary Hepatocytes Follow a Nonlinear Dose Response.Oxidative medicine and cellular longevity · 2017Article
- Infant Infections and Respiratory Symptoms in Relation to in Utero Arsenic Exposure in a U.S. Cohort.Environmental health perspectives · 2016Article
- Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses.Archives of toxicology · 2014Article
- In utero and early life arsenic exposure in relation to long-term health and disease.Toxicology and applied pharmacology · 2013Review
- Arsenic exposure and impaired lung function. Findings from a large population-based prospective cohort study.American journal of respiratory and critical care medicine · 2013Article
- In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice.BMC pharmacology & toxicology · 2013Article
- In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice.Environmental health perspectives · 2013Article
- Delayed temporal increase of hepatic Hsp70 in ApoE knockout mice after prenatal arsenic exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Phenotypic changes in cultured smooth muscle cells: limitation or opportunity for tissue engineering of hollow organs?Journal of tissue engineering and regenerative medicine · 2012Article
- Arsenic exposure to killifish during embryogenesis alters muscle development.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Arsenic toxicology: translating between experimental models and human pathology.Environmental health perspectives · 2011Review
- Impact of environmental chemicals on lung development.Environmental health perspectives · 2010Review
- Arsenic exposure perturbs epithelial-mesenchymal cell transition and gene expression in a collagen gel assay.Toxicological sciences : an official journal of the Society of Toxicology · 2010Article
- In utero and postnatal exposure to arsenic alters pulmonary structure and function.Toxicology and applied pharmacology · 2009Article
- Arsenic inhibits stem cell differentiation by altering the interplay between the Wnt3a and Notch signaling pathways.Toxicology reportsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In the present study, we characterize the toxic effects of in utero arsenic exposure on the developing lung. We hypothesize that in utero exposure to inorganic arsenic through maternal drinking water causes altered gene and protein expression in the developing lung, indicative of downstream molecular and functional changes. From conception to embryonic day 18, we exposed pregnant Sprague-Dawley rats to 500 ppb arsenic (as arsenite) via the drinking water. Subtracted cDNA libraries comparing control to arsenic exposed embryonic lungs were generated. In addition, a broad Western blot analysis was performed to identify altered protein expression. A total of 59 genes and 34 proteins were identified as being altered. Pathway mapping and analysis showed that cell motility was the process most affected. The most likely affected pathway was alteration in integrin signaling through the beta-catenin pathway, altering c-myc. The present study shows that arsenic induces alterations in the developing lung. These data may be useful in the elucidation of molecular targets and biomarkers of arsenic exposure during lung development and may aid in understanding the etiology of arsenic induced adult respiratory disease and lung cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.