ArticleTissue engineering. Part A2009
In vivo comparison of biomimetic approaches for tissue regeneration of the scarred vocal fold.
Article in Tissue engineering. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Prospective multi-arm evaluation of surgical treatments for vocal fold scar and pathologic sulcus vocalis.The Laryngoscope · 2011Trial
- Human amniotic epithelial cell transplantation improves scar remodeling in a rabbit model of acute vocal fold injury: a pilot study.Stem cell research & therapy · 2022Article
- Paired versus two-group experimental design for rheological studies of vocal fold tissues.Journal of biomechanics · 2019Article
- Adipose-Derived Mesenchymal Stromal Cells Persist in Tissue-Engineered Vocal Fold Replacement in Rabbits.The Annals of otology, rhinology, and laryngology · 2018Article
- Comparative characteristics of laryngeal-resident mesenchymal stromal cell populations isolated from distinct sites in the rat larynx.Stem cell research & therapy · 2017Article
- Tissue engineering-based therapeutic strategies for vocal fold repair and regeneration.Biomaterials · 2016Review
- MERS versus Standard Surgical Approaches for Porcine Vocal Fold Scarring with Adipose Stem Cell Constructs.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2016Article
- Mesenchymal stromal cell injection promotes vocal fold scar repair without long-term engraftment.Cytotherapy · 2016Article
- Tissue-Engineered Vocal Fold Mucosa Implantation in Rabbits.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2016Article
- Investigation of the Viability, Adhesion, and Migration of Human Fibroblasts in a Hyaluronic Acid/Gelatin Microgel-Reinforced Composite Hydrogel for Vocal Fold Tissue Regeneration.Advanced healthcare materials · 2016Article
- Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar.Stem cells international · 2016Article
- Functional and Histological Evaluation following Canine Vocal Fold Reconstruction Using Composite Thyroid Ala Perichondrium Flaps.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2015Article
- Fibroblast-like cells differentiated from adipose-derived mesenchymal stem cells for vocal fold wound healing.PloS one · 2014Article
- Transient dynamic mechanical properties of resilin-based elastomeric hydrogels.Frontiers in chemistry · 2014Article
- Influence of glycosaminoglycan identity on vocal fold fibroblast behavior.Acta biomaterialia · 2011Article
- The effect of mesenchymal stromal cell-hyaluronic acid hydrogel constructs on immunophenotype of macrophages.Tissue engineering. Part A · 2011Article
- Material parameter computation for multi-layered vocal fold models.The Journal of the Acoustical Society of America · 2011Article
- Regenerative medicine as applied to solid organ transplantation: current status and future challenges.Transplant international : official journal of the European Society for Organ Transplantation · 2011Review
- In Vivo engineering of the vocal fold ECM with injectable HA hydrogels-late effects on tissue repair and biomechanics in a rabbit model.Journal of voice : official journal of the Voice Foundation · 2011Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The objective of this study was to determine if three different biomimetic approaches could facilitate tissue regeneration and improve viscoelastic properties in the scarred vocal fold lamina propria extracellular matrix (ECM). Twenty rabbit vocal folds were biopsied bilaterally; 2 months postinjury rabbits were unilaterally treated with (i) autologous fibroblasts, (ii) a semisynthetic ECM (sECM), or (iii) autologous fibroblasts encapsulated in sECM. Saline was injected as a control into the contralateral fold. Animals were sacrificed 2 months after treatment. Outcomes measured were procollagen, collagen, and fibronectin levels in the lamina propria, and tissue viscosity and elasticity across three frequency decades. All treatment groups demonstrated accelerated proliferation of the ECM. Vocal fold lamina propria treated with autologous fibroblasts were found to have significantly improved viscosity (p = 0.0077) and elasticity (p = 0.0081) compared to saline. This treatment group had significantly elevated fibronectin levels. sECM and autologous fibroblasts/sECM groups had significantly elevated levels of procollagen, collagen, and fibronectin, indicating abundant matrix production as compared to saline with viscoelastic measures that did not differ statistically from controls. The use of autologous fibroblasts led to better restoration of the vocal fold lamina propria biomechanical properties. Optimization of cell-scaffold interactions and subsequent cell behavior is necessary for utilization of scaffold and scaffold-cell approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.