ArticlePLoS biology2008
The maternally expressed WRKY transcription factor TTG2 controls lethality in interploidy crosses of Arabidopsis.
Article in PLoS biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A survey of triploid block inconsistency: potential mechanisms and evolutionary implications on polyploid speciation.Journal of experimental botany · 2025Pooled it
- Molecular understanding of plant pollination, fertilization, seed development and protoplast regeneration.Science China. Life sciences · 2026Review
- Samplify: a versatile tool for image-based segmentation and annotation of seed abortion phenotypes.The New phytologist · 2026Article
- A maize mutant in the glutamate receptor-like dwarf13 is modified by cis-acting natural variation and a cornichon homolog.PLoS genetics · 2025Article
- Article
- The role of cytokinin receptors in Arabidopsis thaliana seed development and how they affect the metabolomic profile.Planta · 2025Article
- Decoding hybridization barriers: the molecular and genetic orchestration of the triploid block in Arabidopsis thaliana.BMC plant biology · 2025Review
- Parental dialectic: Epigenetic conversations in endosperm.Current opinion in plant biology · 2024Review
- Molecular basis and evolutionary drivers of endosperm-based hybridization barriers.Plant physiology · 2024Review
- Genetic interaction between TTG2 and AtPLC1 reveals a role for phosphoinositide signaling in a co-regulated suite of Arabidopsis epidermal pathways.Scientific reports · 2024Article
- Evolutionary studies of the bHLH transcription factors belonging to MBW complex: their role in seed development.Annals of botany · 2023Review
- Maternal control of triploid seed development by the TRANSPARENT TESTA 8 (TT8) transcription factor in Arabidopsis thaliana.Scientific reports · 2023Article
- Understanding and overcoming hybrid lethality in seed and seedling stages as barriers to hybridization and gene flow.Frontiers in plant science · 2023Review
- Triggers and mediators of epigenetic remodeling in plants.Frontiers in epigenetics and epigenomics · 2023Review
- Genetic and environmental manipulation ofFrontiers in plant science · 2023Article
- Exploring the genetic potential of Pakistani soybean cultivars through RNA-seq based transcriptome analysis.Molecular biology reports · 2022Article
- Postzygotic reproductive isolation established in the endosperm: mechanisms, drivers and relevance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Article
- Morphological Features of the Anther Development in Tomato Plants with Non-Specific Male Sterility.Biology · 2020Article
- Article
4 more citing papers are in PubMed but not listed here.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The molecular mechanisms underlying lethality of F1 hybrids between diverged parents are one target of speciation research. Crosses between diploid and tetraploid individuals of the same genotype can result in F1 lethality, and this dosage-sensitive incompatibility plays a role in polyploid speciation. We have identified variation in F1 lethality in interploidy crosses of Arabidopsis thaliana and determined the genetic architecture of the maternally expressed variation via QTL mapping. A single large-effect QTL, DR. STRANGELOVE 1 (DSL1), was identified as well as two QTL with epistatic relationships to DSL1. DSL1 affects the rate of postzygotic lethality via expression in the maternal sporophyte. Fine mapping placed DSL1 in an interval encoding the maternal effect transcription factor TTG2. Maternal parents carrying loss-of-function mutations in TTG2 suppressed the F1 lethality caused by paternal excess interploidy crosses. The frequency of cellularization in the endosperm was similarly affected by both natural variation and ttg2 loss-of-function mutants. The simple genetic basis of the natural variation and effects of single-gene mutations suggests that F1 lethality in polyploids could evolve rapidly. Furthermore, the role of the sporophytically active TTG2 gene in interploidy crosses indicates that the developmental programming of the mother regulates the viability of interploidy hybrid offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.