ArticleNanomedicine : nanotechnology, biology, and medicine2009
Self-associated indisulam in phospholipid-based nanomicelles: a potential nanomedicine for cancer.
Article in Nanomedicine : nanotechnology, biology, and medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives.International journal of molecular sciences · 2024Review
- Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rats.Acta pharmaceutica Sinica. B · 2020Article
- pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury.ACS applied materials & interfaces · 2019Article
- Characterization of 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[Methoxy(polyethylene glycerol)-2000] and Its Complex with Doxorubicin Using Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics.Bioconjugate chemistry · 2017Article
- A pH-Sensitive Nanocarrier for Tumor Targeting : Delivery of Ruthenium Complex for Tumor Theranostic by pH-Sensitive Nanocapsule.Pharmaceutical research · 2016Article
- Intestinal absorption of fluorescently labeled nanoparticles.Nanomedicine : nanotechnology, biology, and medicine · 2015Article
- Cabozantinib Loaded DSPE-PEGBAOJ pharmaceutical sciences · 2015Article
- Peptide-micelle hybrids containing fasudil for targeted delivery to the pulmonary arteries and arterioles to treat pulmonary arterial hypertension.Journal of pharmaceutical sciences · 2014Article
- A new lipid-based nano formulation of vinorelbine.AAPS PharmSciTech · 2014Article
- Overview of the role of nanotechnological innovations in the detection and treatment of solid tumors.International journal of nanomedicine · 2014Review
- VIP-targeted Cytotoxic Nanomedicine for Breast Cancer.Drug delivery and translational research · 2012Article
- Intelligent design of multifunctional lipid-coated nanoparticle platforms for cancer therapy.Therapeutic delivery · 2012Review
- Solubilization of beclomethasone dipropionate in sterically stabilized phospholipid nanomicelles (SSMs): physicochemical and in vitro evaluations.Drug design, development and therapy · 2012Article
- Structure and dynamics of highly PEG-ylated sterically stabilized micelles in aqueous media.Journal of the American Chemical Society · 2011Article
- Rehydrated sterically stabilized phospholipid nanomicelles of budesonide for nebulization: physicochemical characterization and in vitro, in vivo evaluations.International journal of nanomedicine · 2011Article
- Nanomicelles loaded with doxorubicin and curcumin for alleviating multidrug resistance in lung cancer.International journal of nanomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
This study aimed to begin development of a nanomedicine containing indisulam solubilized in sterically stabilized micelles (SSMs) composed of DSPE-PEG(2000) or sterically stabilized mixed micelles (SSMMs) composed of DSPE-PEG(2000) plus egg phosphatidylcholine. Micelles were prepared by co-precipitation and reconstitution of drug and lipids. Particle size distributions of micellar formulations were determined by quasi-elastic light scattering. Amounts of solubilized drug were determined by reverse-phase high-performance liquid chromatography (RP-HPLC). In vitro cytotoxicity of indisulam in nanocarrier was determined on the MCF-7 cell line by the National Cancer Institute-developed sulforhodamine B assay. Optimal solubilized indisulam concentrations in 5 mM total lipid were 10 microg/mL for SSMMs and 400 microg/mL for SSMs. HPLC results demonstrated that the encapsulation capacity of both micelles was over 95%. In vitro studies showed that indisulam in micellar system was more effective than free indisulam. The optimized formulation was successfully freeze-dried without any addition of lyoprotectants or cryoprotectants. We conclude that SSMs are a promising nanocarrier for indisulam, and indisulam-SSMs should be developed further as a novel targeted nanomedicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.