Evidence map›Paper›PMID 19070882›Full record

ArticleVirology2009

Identification of a RELIK orthologue in the European hare (Lepus europaeus) reveals a minimum age of 12 million years for the lagomorph lentiviruses.

Z Keckesova, L M J Ylinen, G J Towers, R J Gifford, A Katzourakis

Abstract read
In one paragraph

Article in Virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
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  4. Review
  5. CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
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  7. Review
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  9. Article
  10. Whole-genome comparison of endogenous retrovirus segregation across wild and domestic host species populations.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  11. Origin of the retroviruses: when, where, and how?Current opinion in virology · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Z KeckesovaDepartment of Zoology, University of Oxford, Oxford, UK.
L M J Ylinen
G J Towers
R J Gifford
A Katzourakis
University College London · GBUniversity of Oxford · GBStanford University · US

Funding

Medical Research Council G0801172Medical Research Council G0801172(87743)Medical Research Council G9721629Wellcome Trust 076608
6 · The paper itself

Abstract

The retroviral genus Lentivirus comprises retroviruses characterised from five mammalian orders. Lentiviruses typically undergo rapid rates of evolution, a feature that has allowed recent evolutionary relationships to be elucidated, but has also obscured their distant evolutionary past. However, the slowdown in the rate of evolution associated with genome invasion, as has occurred in the European rabbit, enables longer-term lentiviral evolutionary history to be inferred. Here we report the identification of orthologous RELIK proviruses in the European hare, demonstrating a minimum age of 12 million years for the lagomorph lentiviruses. This finding indicates an association between lentiviruses and their hosts covering much of the evolutionary history of the lagomorphs, and taking place within species with a worldwide distribution.

Indexed as

Biological EvolutionAnimalsBase SequenceCell LineConserved SequenceDNADNA, ViralEndogenous RetrovirusesGenetic VariationHaresHeLa CellsHumansLentivirusMammalsMolecular Sequence DataPhylogenyDNADNA, Viral

Identifiers

PMID19070882
PMCPMC3556577
OpenAlexW2034456780

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.