Evidence map›Paper›PMID 19070783›Full record

ArticleMethods (San Diego, Calif.)2009

RNA polymerase: a nexus of gene regulation.

John D Helmann

Abstract read
In one paragraph

Article in Methods (San Diego, Calif.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Adaptive laboratory evolution ofMicrobiology (Reading, England) · 2020
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

John D HelmannDepartment of Microbiology, Cornell University, 327 Wing Hall, Ithaca, NY 14853-8101, USA. jdh9@cornell.edu
Cornell University · US

Funding

STRUCTURAL STUDIES OF BACILLUS SUBTILIS SIGMA FACTORSR01GM047446 · NIGMS · CORNELL UNIVERSITY ITHACA · PI HELMANN, JOHN D · 1992 to 2016
$6.7M
Zinc Homeostasis in Bacillus subtilisR01GM059323 · NIGMS · CORNELL UNIVERSITY ITHACA · PI HELMANN, JOHN D · 2000 to 2017
$4.5M
NIGMS NIH HHS GM-047446NIGMS NIH HHS GM-059323NIGMS NIH HHS R01 GM047446NIGMS NIH HHS R01 GM059323
6 · The paper itself

Abstract

In Bacteria, transcription is catalyzed by a single RNA polymerase (RNAP) whose promoter selectivity and activity is governed by a wide variety of transcription factors. The net effect of these transcriptional regulators is to determine which genes are transcribed, and at what levels, under any specific growth condition. RNAP thus serves as a nexus of gene regulation that integrates the information coming from a variety of sensory systems to appropriately modulate gene expression. The techniques presented in this volume provide a set of tools and approaches for investigating the factors controlling RNAP activity at both individual promoters and on a genomic scale. This introductory chapter provides a brief overview of RNAP and the transcription cycle and introduces general principles of how the fundamental steps of transcription are influenced by both DNA (promoter) sequences and trans-acting factors.

Indexed as

DNA-Directed RNA PolymerasesGene Expression Regulation, BacterialPromoter Regions, GeneticRegulatory Elements, TranscriptionalTerminator Regions, GeneticTranscriptional Elongation FactorsTranscription, GeneticTranscription Initiation SiteDNA-Directed RNA PolymerasesTranscriptional Elongation Factors

Identifiers

PMID19070783
PMCPMC3022018
OpenAlexW2009659277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.