ArticleJournal of hepatology2009
The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States.
Article in Journal of hepatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 88 citations in OpenAlex.
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- Genome-wide association study identifies three PNPLA3/SAMM50 SNPs associated with HCC development in non-viral liver disease.JHEP reports : innovation in hepatology · 2026Article
- Risk and Prognosis of Hepatocellular Carcinoma in Mexican Americans with Type 2 Diabetes Mellitus.Journal of hepatocellular carcinoma · 2025Article
- Liver histology pattern of young patients with inactive chronic hepatitis b virus infection from a hospital in South West Nigeria.BMC gastroenterology · 2024Article
- Genetic screening of liver cancer: State of the art.World journal of hepatology · 2024Review
- [Limitations and cautions of a family history of HBV-related cirrhosis/hepatocellular carcinoma as a condition for initiating antiviral therapy in patients with HBV infection].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023Article
- Genetic Susceptibility to Hepatocellular Carcinoma in Patients with Chronic Hepatitis Virus Infection.Viruses · 2023Review
- [Age and family history should be fully considered when initiating antiviral therapy in chronic HBV infection patients with persistently normal alanine aminotransferase].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- [Why not both patient's age and family history should be necessary as the criteria for initiating treatment of patients with chronic HBV infection?]Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- Risk scores to predict HCC and the benefits of antiviral therapy for CHB patients in gray zone of treatment guidelines.Hepatology international · 2021Article
- Association of dietary fat intake and hepatocellular carcinoma among US adults.Cancer medicine · 2021Article
- Prediction of the risk of developing hepatocellular carcinoma in health screening examinees: a Korean cohort study.BMC cancer · 2021Article
- Risk Factors and Biomarkers for Chronic Hepatitis B Associated Hepatocellular Carcinoma.International journal of molecular sciences · 2021Review
- Hepatocellular carcinoma in Senegal: epidemiological, clinical and etiological aspects about 229 cases atThe Pan African medical journal · 2021Article
- Clinical Features and Overall Survival of Females with Hepatocellular Carcinoma: A Retrospective Study and Review of the Literature in the Association of Southeast Asian Nations.International journal of women's health · 2021Article
- Multigene Panel Testing in Individuals With Hepatocellular Carcinoma Identifies Pathogenic Germline Variants.JCO precision oncology · 2021Article
- Multiple Roles for Hepatitis B and C Viruses and the Host in the Development of Hepatocellular Carcinoma.Hepatology (Baltimore, Md.) · 2021Review
- Risk factors for hepatocellular carcinoma (HCC) in the northeast of the United States: results of a case-control study.Cancer causes & control : CCC · 2020Article
- Association of family history with long-term prognosis in patients undergoing liver resection of HBV-related hepatocellular carcinoma.Hepatobiliary surgery and nutrition · 2019Article
- Generic chemoprevention of hepatocellular carcinoma.Annals of the New York Academy of Sciences · 2019Review
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsThe study aimed at addressing the connection between positive family history of liver cancer and hepatocellular carcinoma (HCC) development in the USA.
methodsAt The University of Texas M.D. Anderson Cancer Center, 347 patients with pathologically confirmed HCC and 1075 healthy controls were studied. All subjects were interviewed for their family history of cancer, including the number of relatives with cancer, the type of cancer, the individual's relationship with the relative, and the age at which the relative was diagnosed.
resultsIndependently of hepatitis B virus (HBV) and hepatitis C virus (HCV), a history of liver cancer in first degree relatives was significantly associated with HCC development (AOR=4.1 [95% CI, 1.3-12.9]). Multiple relatives with liver cancer were only observed among HCC patients with chronic HBV/HCV infection. Affected siblings with liver cancer is significantly associated with HCC development with and without HBV/HCV infection; (AOR=5.7 [95% CI, 1.2-27.3]) and (AOR=4.3 [95% CI, 1.01-20.9]), respectively. Individuals with HBV/HCV and a family history of liver cancer were at higher risk for HCC (AOR=61.9 [95% CI, 6.6-579.7]).
conclusionsFirst degree family history of liver cancer is associated with HCC development in the USA. Further research exploring the genetic-environment interactions associated with risk of HCC is warranted.
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