ArticleThe Journal of biological chemistry2009
Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- Small-Molecule Inhibitors Targeting FEN1 for Cancer Therapy.Biomolecules · 2022Review
- FEN1 is a prognostic biomarker for ER+ breast cancer and associated with tamoxifen resistance through the ERα/cyclin D1/Rb axis.Annals of translational medicine · 2021Article
- The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells.Experimental cell research · 2017Article
- Requirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis.The Plant journal : for cell and molecular biology · 2016Article
- Regulating telomere length from the inside out: the replication fork model.Genes & development · 2016Article
- RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.The Biochemical journal · 2015Article
- A novel method for monitoring functional lesion-specific recruitment of repair proteins in live cells.Mutation research · 2015Article
- DNA-Directed Polymerase Subunits Play a Vital Role in Human Telomeric Overhang Processing.Molecular cancer research : MCR · 2015Article
- Article
- The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers.Oncogene · 2015Article
- Flap endonuclease 1.Annual review of biochemistry · 2013Review
- Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in.Cell research · 2012Article
- Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells.Cellular and molecular life sciences : CMLS · 2012Article
- The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus.The Biochemical journal · 2011Article
- Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer.Cell research · 2011Article
- Mapping the FEN1 interaction domain with hTERT.Biochemical and biophysical research communications · 2011Article
- Functional regulation of FEN1 nuclease and its link to cancer.Nucleic acids research · 2011Review
- Telomere replication: poised but puzzling.Journal of cellular and molecular medicine · 2011Review
- CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Studies from budding yeast and ciliates have suggested that telomerase extension of telomeres requires the conventional DNA replication machinery, yet little is known about how DNA replication proteins regulate telomerase action in higher eukaryotic cells. Here we investigate the role of one of the DNA replication factors, flap endonuclease I (FEN1), in regulating telomerase activity in mammalian cells. FEN1 is a nuclease that plays an important role in DNA replication, repair, and recombination. We show that FEN1 is in complex with telomerase in vivo via telomeric DNA. We further demonstrate that FEN1 deficiency in mouse embryonic fibroblasts leads to an increase in telomere end-to-end fusions. In cancer cells, FEN1 deficiency induces gradual shortening of telomeres but does not alter the single-stranded G-overhangs. This is, to our knowledge, the first evidence that FEN1 and telomerase physically co-exist as a complex and that FEN1 can regulate telomerase activity at telomeres in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.