ArticleParasite immunology
Regulation of toll-like receptors in intestinal epithelial cells by stress and Toxoplasma gondii infection.
Article in Parasite immunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- IL-37/IL-1R8 axis: a novel major mechanism of control at the interface between tumor and immune cells.Oncoimmunology · 2026Review
- Exploring the potential of Toxoplasma gondii in drug development and as a delivery system.Experimental & molecular medicine · 2024Review
- From Entry to Early Dissemination-Frontiers in cellular and infection microbiology · 2019Review
- Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8.Immunological reviews · 2018Review
- Regulatory Role of IL-1R8 in Immunity and Disease.Frontiers in immunology · 2016Review
- Role of glucocorticoids and Toxoplasma gondii infection on murine intestinal epithelial cells.Parasitology international · 2014Article
- Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis.Pathophysiology : the official journal of the International Society for Pathophysiology · 2014Article
- Reduction in cryptosporidiosis associated with introduction of enhanced filtration of drinking water at Loch Katrine, Scotland.Epidemiology and infection · 2014Article
- Decoys and Regulatory "Receptors" of the IL-1/Toll-Like Receptor Superfamily.Frontiers in immunology · 2013Article
- Intestinal epithelial cells modulate antigen-presenting cell responses to bacterial DNA.Infection and immunity · 2012Article
- Transcriptome signature in young children with acute otitis media due to Streptococcus pneumoniae.Microbes and infection · 2012Article
- TIR8/SIGIRR is an Interleukin-1 Receptor/Toll Like Receptor Family Member with Regulatory Functions in Inflammation and Immunity.Frontiers in immunology · 2012Article
- Toll-like receptor activation by helminths or helminth products to alleviate inflammatory bowel disease.Parasites & vectors · 2011Review
- Gut feelings: the emerging biology of gut-brain communication.Nature reviews. Neuroscience · 2011Review
- Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function.Nature reviews. Immunology · 2010Review
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Intestinal epithelial cells (IECs) form a barrier between invading microorganisms and the underlying host tissues. IECs express toll-like receptors (TLRs) that recognize specific molecular signatures on microbes, which activate intracellular signalling pathways leading to production of proinflammatory cytokines and chemokines. Stress hormones play an important role in modulation of proinflammatory cytokines and down-regulation of immune responses. Here we demonstrated that expression levels of TLR-2, TLR-4, TLR-9 and TLR-11 were significantly increased in mouse IECs following infection with Toxoplasma gondii on day 8 postinfection. In contrast, expression of TLRs was significantly decreased in infected mice subjected to cold water stress (CWS + INF). Expression of TLR-9 and TLR-11 in the mouse MODE-K cell line was significantly increased after infection. Expression of TLR-9 and TLR-11 in cells exposed to norepinephrine (NE) and parasites was significantly decreased when compared to cells exposed to parasites only. A significant increase was observed in SIGIRR, a negative regulator of TLRs in the CWS + INF group when compared to the INF group. Stress components were able to decrease expression levels of TLRs in IECs, decrease parasite load, and increase expression of a negative regulator thereby ameliorating intestinal inflammatory responses commonly observed during per oral T. gondii infection in C57BL/6 mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.