ReviewClinical infectious diseases : an official publication of the Infectious Diseases Society of America2009
Diagnostic testing or empirical therapy for patients hospitalized with suspected influenza: what to do?
Review in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Seasonal influenza in adults and children--diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Guideline
- Evaluation of Influenza A H1N1 infection and antiviral utilization in a tertiary care hospital.BMC infectious diseases · 2018Article
- Factors influencing the diagnostic accuracy of the rapid influenza antigen detection test (RIADT): a cross-sectional study.BMJ open · 2014Article
- Influenza surveillance in Europe: establishing epidemic thresholds by the moving epidemic method.Influenza and other respiratory viruses · 2013Article
- A microfluidic immunomagnetic bead-based system for the rapid detection of influenza infections: from purified virus particles to clinical specimens.Biomedical microdevices · 2013Article
- Estimating influenza deaths in Canada, 1992-2009.PloS one · 2013Article
- Clinical and demographic characteristics of seasonal influenza in pediatric patients with cancer.The Pediatric infectious disease journal · 2012Article
- Infectious Disease Management through Point-of-Care Personalized Medicine Molecular Diagnostic Technologies.Journal of personalized medicine · 2012Review
- A cost-effectiveness analysis of "test" versus "treat" patients hospitalized with suspected influenza in Hong Kong.PloS one · 2012Article
- When should a diagnosis of influenza be considered in adults requiring intensive care unit admission? Results of population-based active surveillance in Toronto.Critical care (London, England) · 2011Article
- [Characteristics of lower respiratory tract infections in the elderly].Antibiotiques (Paris, France : 1999) · 2010Article
- End points for testing influenza antiviral treatments for patients at high risk of severe and life-threatening disease.The Journal of infectious diseases · 2010Review
- Field performance of a rapid diagnostic test for influenza in an ambulatory setting.Journal of clinical microbiology · 2009Article
- Viral loads and duration of viral shedding in adult patients hospitalized with influenza.The Journal of infectious diseases · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence supports the use of specific diagnostic tests and antiviral therapies for seriously ill patients with influenza. Among available diagnostic tests, reverse-transcriptase polymerase chain reaction is faster than culture and more sensitive than commercial antigen assays. Current neuraminidase inhibitors were approved on the basis of their efficacy in ambulatory patients, but seriously ill patients who receive these agents are less likely to die, even when treatment is initiated >48 h after symptom onset. For patients hospitalized with suspected influenza, it is unclear which circumstances warrant diagnostic testing and which warrant the use of empirical therapy. Rapid antigen assays may reduce the unnecessary use of other tests and medications but are relatively insensitive, thus eliminating many patients with influenza as candidates for treatment. Empirical antiviral therapy ensures that all patients receive treatment promptly, at a cost equivalent to that of diagnostic tests alone, but results in the receipt of treatment by many patients without influenza. For patients hospitalized with suspected influenza, clinicians need to combine these approaches in order to optimize patient care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.