ArticlePLoS biology2008
Kin discrimination increases with genetic distance in a social amoeba.
Article in PLoS biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- Aggregative chimeric multicellularity in the absence of lethal kin discrimination.The ISME journal · 2026Article
- Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Testing the coordination hypothesis: incompatibilities in aggregative development of an experimentally evolved social amoeba.Evolution letters · 2025Article
- mTORC1 pathway activity biases cell fate choice.Scientific reports · 2024Article
- The greenbeard gene tgrB1 regulates altruism and cheating in Dictyostelium discoideum.Nature communications · 2024Article
- In the social amoebaPeerJ · 2024Article
- Reduced social function in experimentally evolvedProceedings. Biological sciences · 2023Article
- Minor variations in multicellular life cycles have major effects on adaptation.PLoS computational biology · 2023Article
- Developmental constraints enforce altruism and avert the tragedy of the commons in a social microbe.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cryptic surface-associated multicellularity emerges through cell adhesion and its regulation.PLoS biology · 2021Article
- WildEcology and evolution · 2020Article
- Suicidal selection: Programmed cell death can evolve in unicellular organisms due solely to kin selection.Ecology and evolution · 2019Article
- Bacteria from natural populations transfer plasmids mostly towards their kin.Proceedings. Biological sciences · 2019Article
- Discrimination Experiments in Entamoeba and Evidence from Other Protists Suggest Pathogenic Amebas Cooperate with Kin to Colonize Hosts and Deter Rivals.The Journal of eukaryotic microbiology · 2019Review
- Cellular allorecognition and its roles in Dictyostelium development and social evolution.The International journal of developmental biology · 2019Review
- Species recognition in social amoebae.Journal of biosciences · 2018Article
- Strategic investment explains patterns of cooperation and cheating in a microbe.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cell adhesion and fluid flow jointly initiate genotype spatial distribution in biofilms.PLoS computational biology · 2018Article
- Indirect evolution of social fitness inequalities and facultative social exploitation.Proceedings. Biological sciences · 2018Article
- Genetic signatures of microbial altruism and cheating in social amoebas in the wild.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
11 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
Abstract
In the social amoeba Dictyostelium discoideum, thousands of cells aggregate upon starvation to form a multicellular fruiting body, and approximately 20% of them die to form a stalk that benefits the others. The aggregative nature of multicellular development makes the cells vulnerable to exploitation by cheaters, and the potential for cheating is indeed high. Cells might avoid being victimized if they can discriminate among individuals and avoid those that are genetically different. We tested how widely social amoebae cooperate by mixing isolates from different localities that cover most of their natural range. We show here that different isolates partially exclude one another during aggregation, and there is a positive relationship between the extent of this exclusion and the genetic distance between strains. Our findings demonstrate that D. discoideum cells co-aggregate more with genetically similar than dissimilar individuals, suggesting the existence of a mechanism that discerns the degree of genetic similarity between individuals in this social microorganism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.