ArticleBirth defects research. Part A, Clinical and molecular teratology2009
Maternal vasoactive exposures, amniotic bands, and terminal transverse limb defects.
Article in Birth defects research. Part A, Clinical and molecular teratology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Preconception care: screening and management of chronic disease and promoting psychological health.Reproductive health · 2014Pooled it
- Pooled it
- Assessing the Impact of Exposure Misclassification in Case-Control Studies of Self-Reported Medication Use.Paediatric and perinatal epidemiology · 2026Article
- A multidisciplinary and structured investigation of three suspected clusters of transverse upper limb reduction defects in France.European journal of epidemiology · 2024Article
- Maternal Cigarette Smoking and Congenital Upper and Lower Limb Differences: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Prevalence of vascular disruption anomalies and association with young maternal age: A EUROCAT study to compare the United Kingdom with other European countries.Birth defects research · 2022Article
- Maternal Risk Factors Associated with Limb Reduction Defects: Data from the Polish Registry of Congenital Malformations (PRCM).Children (Basel, Switzerland) · 2021Article
- Vasoactive exposures and risk of amniotic band syndrome and terminal transverse limb deficiencies.Birth defects research · 2020Article
- Symmetrical terminal transverse limb deficiencies.Indian journal of pediatrics · 2015Article
- Challenges in Studying Modifiable Risk Factors for Birth Defects.Current epidemiology reports · 2015Article
- Amniotic band syndrome with sacral agenesis and umbilical cord entrapment: A case report emphasizing the value of evaluation of umbilical cord.Journal of radiology case reports · 2015Article
- Maternal periconceptional exposure to cigarette smoking and congenital limb deficiencies.Paediatric and perinatal epidemiology · 2013Article
- Vasoactive exposures during pregnancy and risk of microtia.Birth defects research. Part A, Clinical and molecular teratology · 2013Article
- Epidemiology and risk factors of amniotic band syndrome, or ADAM sequence.Journal of prenatal medicine · 2012Article
- Is maternal parity an independent risk factor for birth defects?Birth defects research. Part A, Clinical and molecular teratology · 2012Article
- Nonsteroidal antiinflammatory drug use among women and the risk of birth defects.American journal of obstetrics and gynecology · 2012Article
- Maternal dietary glycaemic intake during pregnancy and the risk of birth defects.Paediatric and perinatal epidemiology · 2011Article
- 4D scanning: a diagnostic tool of choice for detection of fetal limb reduction defects.BMJ case reports · 2011Article
- Exposure to non-steroidal anti-inflammatory drugs during pregnancy and the risk of selected birth defects: a prospective cohort study.PloS one · 2011Article
- Amniotic band syndrome and/or limb body wall complex: split or lump.The application of clinical genetics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLimb reduction deficiencies that are accompanied by amniotic bands (AB-Ls) and terminal transverse limb deficiencies (TLDs) have each been attributed to vascular disruption; for the former, however, it is not clear if amniotic bands are the primary cause of or are secondary to vascular disruption. If amniotic bands are secondary to vascular disruption, then a shared pathogenesis for each case group might be exhibited by similar risk factors.
methodsWe evaluated maternal age, education, race/ethnicity, parity, pregnancy wantedness, and vasoactive exposures among 139 AB-L and 373 TLD cases, using interview data collected from mothers in 10 states by the National Birth Defects Prevention Study. Vasoactive exposures included maternal cigarette smoking and use of decongestants, nonsteroid anti-inflammatory drugs, and antihypertensive drugs in the periconceptional period.
resultsIncreased risk estimates were observed for Black mothers (OR 2.5; 95% CI: 1.5-4.1) and nulliparous mothers (2.1; 1.4-3.0) in relation to AB-L, while neither was associated with TLD. Hispanic women (1.4; 1.0-1.9) and those not wanting the pregnancy (1.5; 1.1-2.1) had increased risks of TLD, but not AB-L. Maternal cigarette smoking and aspirin use each increased the risk of AB-L, but not TLD; while decongestants and possibly antihypertensive medications increased the risk of TLD, but not AB-L.
conclusionsThe lack of consistent findings for the two case groups suggests that AB-L and TLD may be distinct entities. The inconsistencies also suggest that these vasoactive exposures may not be markers for vascular disruption or that vascular disruption may not play a major role in the pathogenesis of these two types of limb deficiencies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.