Evidence map›Paper›PMID 19067326›Full record

ArticleHuman brain mapping2009

Can structural MRI indices of cerebral integrity track cognitive trends in executive control function during normal maturation and adulthood?

Peter Kochunov, Don A Robin, Don R Royall, Thomas Coyle, Jack Lancaster, Valeria Kochunov, Anita E Schlosser, Peter T Fox

Abstract read
In one paragraph

Article in Human brain mapping, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter KochunovResearch Imaging Center, University of Texas Health Science Center at San Antonio, Texas 78284, USA. kochunov@uthscsa.edu
Don A Robin
Don R Royall
Thomas Coyle
Jack Lancaster
Valeria Kochunov
Anita E Schlosser
Peter T Fox

Funding

ZOLEDRONATE VS AREDIA IN MULTIPLE MYELOMA/BREAST CANCER W /BONE DISORDERSM01RR001346 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI WILLIAMSON, DOUGLAS E · 1985 to 2008
$23.1M
COMBINING NEUROIMAGING AND GENETICS FOR HERITABILITY MEASUREMENTSK01EB006395 · NIBIB · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KOCHUNOV, PETER V. · 2007 to 2011
$733k
NCRR NIH HHS M01 RR001346NCRR NIH HHS M01 RR01346NIBIB NIH HHS K01 EB006395NIDA NIH HHS P20 MH/DA52176
6 · The paper itself

Abstract

We explored the relationship between structural neuroimaging-based indices of cerebral integrity and executive control function (ECF) in two groups of healthy subjects: A maturing group (33 subjects; 19-29 years) and a senescing group (38 adults; 30-90 years). ECF was assessed using the Executive Interview (EXIT) battery. Cortical indices of cerebral integrity included GM thickness, intergyral span, and sulcal span, each measured for five cortical regions per hemisphere. Subcortical indices included fractional anisotropy (FA), measured using track-based-spatial-statistics (TBSS), and the volume of T2-hyperintense WM (HWM). In the maturing group, no significant relationships between neuroanatomical changes and ECF were found; however, there were hints that late-term maturation of cerebral WM influenced variability in ECF. In the senescing group, the decline in ECF corresponded to atrophic changes in cerebral WM (sulcal and intergyral span) primarily in the superior frontal and anterior cingulate regions. A large fraction of the variability in ECF (62%) can be explained by variability in the structural indices from these two regions.

Indexed as

AgingMental ProcessesAdultAgedAged, 80 and overAnisotropyBrainCerebral CortexDiffusion Magnetic Resonance ImagingFemaleHumansImaging, Three-DimensionalLinear ModelsMagnetic Resonance ImagingMaleMiddle Aged

Identifiers

PMID19067326
PMCPMC2733910

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.