Trial reportAmerican journal of perinatology2009
Inhaled nitric oxide for preterm premature rupture of membranes, oligohydramnios, and pulmonary hypoplasia.
Trial report in American journal of perinatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Follow-up Visit of High Risk Infants
Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Inhaled nitric oxide for respiratory failure in preterm infants.The Cochrane database of systematic reviews · 2017Pooled it
- Increase in the use of inhaled nitric oxide in neonatal intensive care units in England: a retrospective population study.BMJ paediatrics open · 2021Trial
- Outcomes of extremely preterm infants exposed to prolonged prelabor rupture of membranes before 24 weeks of gestation.American journal of obstetrics and gynecology · 2025Article
- Pulmonary Hemorrhage in Premature Infants: Pathophysiology, Risk Factors and Clinical Management.Biomedicines · 2025Review
- Impact of Pulmonary Hypertension and Patent Ductus Arteriosus in Preterm Infants with Presumed Pulmonary Hypoplasia.Biomedicines · 2025Article
- Retrospective study of preterm infants exposed to inhaled nitric oxide in Kaiser Permanente Southern California: morbidity, mortality and follow-up.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Inhaled Nitric Oxide in Neonatal Pulmonary Hypertension.Clinics in perinatology · 2024Review
- Article
- Response categorization and outcomes in extremely premature infants born at 22-26 weeks gestation that received inhaled nitric oxide for hypoxic respiratory failure.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- The early use of inhaled nitric oxide in premature infants requiring respiratory support.Annals of medicine · 2023Review
- Overview of the neonatal research network: History, contributions, challenges, and future.Seminars in perinatology · 2022Review
- Use of Inhaled Nitric Oxide in Preterm Infants: Is There Sufficient Evidence?Indian journal of pediatrics · 2022Review
- When to say no to inhaled nitric oxide in neonates?Seminars in fetal & neonatal medicine · 2021Review
- The Controversy Persists: Is There a Qualification Criterion to Utilize Inhaled Nitric Oxide in Pre-term Newborns?Frontiers in pediatrics · 2021Review
- Early Hypoxic Respiratory Failure in Extreme Prematurity: Mortality and Neurodevelopmental Outcomes.Pediatrics · 2020Article
- Just Say No to iNO in Preterms-Really?The Journal of pediatrics · 2020Article
- Factors influencing decision making in neonatology: inhaled nitric oxide in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Outcomes of hypoxic respiratory failure at birth associated with previable rupture of membranes.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Association of Early Inhaled Nitric Oxide With the Survival of Preterm Neonates With Pulmonary Hypoplasia.JAMA pediatrics · 2018Article
- Controversies in the identification and management of acute pulmonary hypertension in preterm neonates.Pediatric research · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
We sought to determine if inhaled nitric oxide (iNO) administered to preterm infants with premature rupture of membranes (PPROM), oligohydramnios, and pulmonary hypoplasia improved oxygenation, survival, or other clinical outcomes. Data were analyzed from infants with suspected pulmonary hypoplasia, oligohydramnios, and PPROM enrolled in the National Institute of Child Health and Development Neonatal Research Network Preemie Inhaled Nitric Oxide (PiNO) trial, where patients were randomized to receive placebo (oxygen) or iNO at 5 to 10 ppm. Outcome variables assessed were PaO (2) response, mortality, bronchopulmonary dysplasia (BPD), and severe intraventricular hemorrhage (IVH) or periventricular leukomalacia (PVL). Twelve of 449 infants in the PiNO trial met criteria. Six infants received iNO and six received placebo. The iNO group had a mean increase in PaO (2) of 39 +/- 50 mm Hg versus a mean decrease of 11 +/- 15 mm Hg in the control group. Mortality was 33% versus 67%, BPD (2/5) 40% versus (2/2) 100%, and severe IVH or PVL (1/5) 20% versus (1/2) 50% in the iNO and control groups, respectively. None of these changes were statistically significant. Review of a limited number of cases from a large multicenter trial suggests that iNO use in the setting of PPROM, oligohydramnios, and suspected pulmonary hypoplasia improves oxygenation and may decrease the rate of BPD and death without increasing severe IVH or PVL. However, the small sample size precludes definitive conclusions. Further studies are required to determine if iNO is of benefit in this specific patient population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.