ArticleImmunologic research2009
Thymus transplantation in complete DiGeorge anomaly.
Article in Immunologic research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Parathyroid and Thymus Transplantation in DiGeorge Syndrome, #931
Phase II Study of Thymus Transplantation in Complete DiGeorge Syndrome #668
Dose Study of Thymus Transplantation in DiGeorge Anomaly, IND 9836, #932.1
Phase I/II Trial of Thymus Transplantation With Immunosuppression, #950
Thymus Transplantation With Immunosuppression, #884
Safety and Efficacy of Thymus Transplantation in Complete DiGeorge Anomaly, IND#9836
Expanded Access Protocol Thymus Transplantation for Immunodeficiency, Hematologic Malignancies, and Autoimmune Disease Related to Poor Thymic Function
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Thymus transplantation for DiGeorge Syndrome: a systematic review.Pediatric surgery international · 2025Pooled it
- Recommendations for uniform definitions used in newborn screening for severe combined immunodeficiency.The Journal of allergy and clinical immunology · 2022Pooled it
- Rebooting immunity in congenital athymia: Factors impacting reconstitution with thymus implantation.Journal of human immunity · 2026Article
- Omenn syndrome in a 10-month-old male with athymia and VACTERL association.The journal of allergy and clinical immunology. Global · 2023Article
- Use of pediatric thymus to humanize mice for HIV-1 mucosal transmission.Scientific reports · 2023Article
- Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic Development.Journal of clinical immunology · 2023Review
- Improving thymus implantation for congenital athymia with interleukin-7.Clinical & translational immunology · 2023Article
- Congenital Athymia: Unmet Needs and Practical Guidance.Therapeutics and clinical risk management · 2023Review
- Atopic Dermatitis-like Genodermatosis: Disease Diagnosis and Management.Diagnostics (Basel, Switzerland) · 2022Review
- Positive and negative selection shape the human naive B cell repertoire.The Journal of clinical investigation · 2022Article
- A novel activity on thymocytes cells exerted by the rattlesnake (Crotalus durissus cumanensis) venom.Biomedica : revista del Instituto Nacional de Salud · 2021Article
- Congenital Athymia: Genetic Etiologies, Clinical Manifestations, Diagnosis, and Treatment.Journal of clinical immunology · 2021Review
- Care of Children with DiGeorge Before and After Cultured Thymus Tissue Implantation.Journal of clinical immunology · 2021Article
- Immune Reconstitution After Allogeneic Haematopoietic Cell Transplantation: From Observational Studies to Targeted Interventions.Frontiers in pediatrics · 2021Review
- Immune and Genetic Features of the Chromosome 22q11.2 Deletion (DiGeorge Syndrome).Current allergy and asthma reports · 2018Review
- State of the Art: Role of the Dendritic Cell in Induction of Allograft Tolerance.Transplantation · 2018Review
- A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation.Immunity · 2018Article
- Transplanted human thymus slices induce and support T-cell development in mice after cryopreservation.European journal of immunology · 2018Article
- FOXN1 Deficiency: from the Discovery to Novel Therapeutic Approaches.Journal of clinical immunology · 2017Review
- FOXN1 deficient nude severe combined immunodeficiency.Orphanet journal of rare diseases · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Complete DiGeorge anomaly is characterized by athymia, congenital heart disease, and hypoparathyroidism. This congenital disease is fatal by age 2 years unless immune reconstitution is successful. There are multiple underlying syndromes associated with complete DiGeorge anomaly including 22q11 hemizygosity in approximately 50%, CHARGE association in approximately 25%, and diabetic embryopathy in approximately 15%. Approximately one-third of patients present with rash and lymphadenopathy associated with oligoclonal "host" T cells. This condition resembles Omenn syndrome. Immunosuppression is necessary to control the oligoclonal T cells. The results of thymus transplantation are reported for a series of 50 patients, of whom 36 survive. The survivors develop naïve T cells and a diverse T cell repertoire.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.