ArticleThe Journal of the Canadian Chiropractic Association2008
The effect of a manual therapy knee protocol on osteoarthritic knee pain: a randomised controlled trial.
Article in The Journal of the Canadian Chiropractic Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Relative Effectiveness of Three Full Kinetic Chain Treatment Protocols for Osteoarthritis of the Knee: Manual Therapy, Rehabilitation and a Combination Thereof
Immediate Effects of Manual Therapy Versus TENS in Patients With Knee Osteoarthritis
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- The Efficacy of Manual Therapy in Patients with Knee Osteoarthritis: A Systematic Review.Medicina (Kaunas, Lithuania) · 2021Pooled it
- Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review.The Cochrane database of systematic reviews · 2018Pooled it
- Drug-loaded nanoparticles for intra-articular injection.PloS one · 2026Article
- Voices from the clinic: a qualitative analysis of physiotherapy strategies in musculoskeletal care for knee osteoarthritis patients.BMC musculoskeletal disorders · 2025Article
- Effects of Aquatic Exercises for Patients with Osteoarthritis: Systematic Review with Meta-Analysis.Healthcare (Basel, Switzerland) · 2022Review
- Factors Influencing Pain Management of Patients with Osteoarthritis: A Cross-Sectional Study.Journal of clinical medicine · 2022Article
- Efficacy of Specified Manual Therapies in Combination with a Supervised Exercise Protocol for Managing Pain Intensity and Functional Disability in Patients with Knee Osteoarthritis.Journal of pain research · 2021Article
- Manual Therapy (Postisometric Relaxation and Joint Mobilization) in Knee Pain and Function Experienced by Patients with Rheumatoid Arthritis: A Randomized Clinical Pilot Study.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Effectiveness of home-based physiotherapy on pain and disability in participants with osteoarthritis of knee: an observational study.Journal of physical therapy science · 2018Article
- Innovative application of Cox Flexion Distraction Decompression to the knee: a retrospective case series.The Journal of the Canadian Chiropractic Association · 2017Article
- Quality of reporting of randomised controlled trials in chiropractic using the CONSORT checklist.Chiropractic & manual therapies · 2016Article
- Knee extension range of motion and self-report physical function in total knee arthroplasty: mediating effects of knee extensor strength.BMC musculoskeletal disorders · 2013Article
- Clinical presentation and manual therapy for lower quadrant musculoskeletal conditions.The Journal of manual & manipulative therapy · 2011Article
- A randomized controlled trial of chiropractic management of the lower limb kinetic chain for the treatment of hip osteoarthritis: a study protocol.Journal of chiropractic medicine · 2011Article
- A narrative review of the published chiropractic literature regarding older patients from 2001-2010.The Journal of the Canadian Chiropractic Association · 2011Article
- The epidemiology, etiology, diagnosis, and treatment of osteoarthritis of the knee.Deutsches Arzteblatt international · 2010Review
- Effectiveness of manual therapies: the UK evidence report.Chiropractic & osteopathy · 2010Article
- Rehabilitation Strategies for the Athletic Individual with Early Knee Osteoarthritis.Current sports medicine reportsArticle
- Pragmatism in manual therapy trials for knee osteoarthritis: a systematic review.Archives of physiotherapyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKnee osteoarthritis is a highly prevalent condition with a significant socioeconomic burden to society. It is known to effect sufferers through pain, loss of function and changes in health related quality of life. Management typically involves pharmacologic and/or exercise based therapy approaches to reduce pain. Previous studies have shown multimodal treatment approaches incorporating manual therapy to be efficacious. The aim of this study is to determine if a manual therapy technique knee protocol can alter the self reported pain experienced by a group of chronic knee osteoarthritis sufferers in a randomised controlled trial.
methods43 participants with a chronic, non-progressive history of osteoarthritic knee pain, aged between 47 and 70 years were randomly allocated following a screening procedure to an intervention group (n=26; 18 men and 8 women, mean age 56.5 years) or a control group (n=17; 11 men and 6 women, mean age 54.6 years). Participants were matched for present knee pain intensity measured on a visual analogue scale. The intervention consisted of the Macquarie Injury Management Group Knee Protocol whilst the control involved a non-forceful manual contact to the knee followed by interferential therapy set at zero. Participants received three treatments per week for two consecutive weeks with a follow up immediately after the final treatment. Post-treatment Participants completed 11 questions including present knee pain intensity and feedback regarding their response to treatment utilizing a visual analogue scale. Results were analysed using descriptive statistics.
resultsPrior to the intervention, there was no significant differences in age or present knee pain intensity. Following treatment, the intervention group reported a significant decrease in the present pain severity (mean 1.9) when compared to the control group (mean 3.1). Response to treatment questions indicated that compared to the control group, the intervention group felt the intervention had helped them (intervention mean 7.0; control mean 3.4), felt it decreased their knee symptoms such as crepitus (intervention mean 6.0; control mean 3.4) and improved their knee mobility (intervention mean 6.4; control mean 3.4) and their ability to perform general activities (intervention mean 6.5; control mean 3.8). Importantly the MIMG Knee Protocol intervention group reported no adverse reactions during treatment.
conclusionsA short-term manual therapy knee protocol significantly reduced pain suffered by participants with osteoarthritic knee pain and resulted in improvements in self-reported knee function immediately after the end of the 2 week treatment period.
Indexed as
Identifiers
19066697PMC2597887W2213870083What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.