ReviewCell cycle (Georgetown, Tex.)2008
Stem cell aging: survival of the laziest?
Review in Cell cycle (Georgetown, Tex.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells.Cellular & molecular immunology · 2024Article
- Stimulation of mouse hematopoietic stem cells by angiogenin and DNA preparations.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Article
- Granulocyte colony-stimulating factor acts on lymphoid-biased, short-term hematopoietic stem cells.Haematologica · 2021Article
- Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny.Stem cell reports · 2019Article
- Hematopoietic stem/progenitor involvement in retinal microvascular repair during diabetes: Implications for bone marrow rejuvenation.Vision research · 2017Review
- Ataxia Telangiectasia Mutated Dysregulation Results in Diabetic Retinopathy.Stem cells (Dayton, Ohio) · 2016Article
- Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias.PloS one · 2016Article
- miR-92a Corrects CD34+ Cell Dysfunction in Diabetes by Modulating Core Circadian Genes Involved in Progenitor Differentiation.Diabetes · 2015Article
- Fibrosis and renal aging.Kidney international supplements · 2014Review
- Lifespan differences in hematopoietic stem cells are due to imperfect repair and unstable mean-reversion.PLoS computational biology · 2013Article
- New epigenetic pathway for stemness maintenance mediated by the histone methyltransferase Ezh1.Cell cycle (Georgetown, Tex.) · 2013Article
- Kidney transplantation and the ageing immune system.Nature reviews. Nephrology · 2012Review
- Concise review: hematopoietic stem cell aging, life span, and transplantation.Stem cells translational medicine · 2012Review
- Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone.Haematologica · 2012Article
- CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential.Blood · 2012Article
- Irradiated stem cells and ageing of the haematopoietic system.Radiation and environmental biophysics · 2012Article
- Review
- Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells.The Journal of experimental medicine · 2011Article
- Cells derived from young bone marrow alleviate renal aging.Journal of the American Society of Nephrology : JASN · 2011Article
- Transcriptome profiling and sequencing of differentiated human hematopoietic stem cells reveal lineage-specific expression and alternative splicing of genes.Physiological genomics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The question whether stem cells age remains an enigma. Traditionally, aging was thought to change the properties of hematopoietic stem cells (HSC). We discuss here a new model of stem cell aging that challenges this view. It is now well-established that the HSC compartment is heterogeneous, consisting of epigenetically fixed subpopulations of HSC that differ in self-renewal and differentiation capacity. New data show that the representation of these HSC subsets changes during aging. HSC that generate lymphocyte-rich progeny are depleted, while myeloid-biased HSC are enriched in the aged HSC compartment. Myeloid-biased HSC, even when isolated from young donors, have most of the characteristics that had been attributed to aged HSC. Thus, the distinct behavior of the HSC isolated from aged hosts is due to the accumulation of myeloid-biased HSC. By extension this means that the properties of individual HSC are not substantially changed during the lifespan of the organism and that aged hosts do not contain many aged HSC. Myeloid-biased HSC give rise to mature cells slowly but contribute for a long time to peripheral hematopoiesis. We propose that such slow, "lazy" HSC are less likely to be transformed and therefore may safely sustain hematopoiesis for a long time.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.