ReviewCell cycle (Georgetown, Tex.)2008
Chromatin reassembly signals the end of DNA repair.
Review in Cell cycle (Georgetown, Tex.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- The Chromatin Landscape around DNA Double-Strand Breaks in Yeast and Its Influence on DNA Repair Pathway Choice.International journal of molecular sciences · 2023Review
- Article
- PHF6 promotes non-homologous end joining and G2 checkpoint recovery.EMBO reports · 2020Article
- Alterations in histone acetylation following exposure toRadiation and environmental biophysics · 2018Article
- Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan.International journal of molecular sciences · 2018Review
- X Chromosome Crossover Formation and Genome Stability in Caenorhabditis elegans Are Independently Regulated by xnd-1.G3 (Bethesda, Md.) · 2016Article
- 3R gene expression in chronic lymphocytic leukemia reveals insight into disease evolution.Blood cancer journal · 2016Article
- Epigenetic control of mobile DNA as an interface between experience and genome change.Frontiers in genetics · 2014Review
- Virion factors that target Daxx to overcome intrinsic immunity.Journal of virology · 2013Review
- Sites of acetylation on newly synthesized histone H4 are required for chromatin assembly and DNA damage response signaling.Molecular and cellular biology · 2013Article
- Histone modifications and DNA double-strand break repair after exposure to ionizing radiations.Radiation research · 2013Review
- Overexpression of chromatin assembly factor-1 p60, poly(ADP-ribose) polymerase 1 and nestin predicts metastasizing behaviour of oral cancer.Histopathology · 2012Article
- Regulating DNA replication in plants.Cold Spring Harbor perspectives in biology · 2012Review
- Article
- Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R.PloS one · 2012Article
- Chromatin modifications and the DNA damage response to ionizing radiation.Frontiers in oncology · 2012Article
- Histone H3 lysine 56 acetylation and the response to DNA replication fork damage.Molecular and cellular biology · 2012Article
- Epigenetic disregulation in oral cancer.International journal of molecular sciences · 2012Review
- Mass spectrometric identification of novel lysine acetylation sites in huntingtin.Molecular & cellular proteomics : MCP · 2011Article
- 'Relax and Repair' to restrain aging.Aging · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The packaging of the eukaryotic genome into chromatin provides a formidable obstacle to the machinery that mediates genomic processes such as transcription, repair and replication. The cell solves this accessibility problem during double-strand DNA repair by removing the histone proteins flanking the DNA lesion. Presumably then, the repaired DNA is subsequently reassembled into chromatin in order to allow the epigenetic information to be restored and to repackage and protect the genome. Our recent work has shown that chromatin is indeed reassembled following double-strand break repair in budding yeast. Furthermore, the assembly of the repaired DNA into chromatin is driven by acetylation within the globular domain of histone H3, on lysine 56 (H3 K56Ac). Unexpectedly, we also discovered that H3 K56Ac and chromatin assembly onto the repaired DNA is essential to turn off the DNA damage cell cycle checkpoint. This work demonstrates that reformation of the chromatin structure, not DNA repair per se, is the elusive signal that tells the cell when DNA repair is complete.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.