ArticleAmerican journal of physiology. Endocrinology and metabolism2009
Subcutaneous transplantation of embryonic pancreas for correction of type 1 diabetes.
Article in American journal of physiology. Endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Establishment of subcutaneous transplantation platform for delivering induced pluripotent stem cell-derived insulin-producing cells.PloS one · 2025Article
- Insulin secretion of mixed insulinoma aggregates-gelatin hydrogel microspheres after subcutaneous transplantation.Regenerative therapy · 2018Article
- Application of Multiphoton Microscopy in Dermatological Studies: a Mini-Review.Journal of innovative optical health sciences · 2014Article
- Therapeutic value of brown adipose tissue: Correcting metabolic disease through generating healthy fat.Adipocyte · 2012Article
- Adipose tissue, hormones, and treatment of type 1 diabetes.Current diabetes reports · 2012Review
- Article
- Experimental approaches for high-resolution in vivo imaging of islet of Langerhans biology.Current diabetes reports · 2011Review
- Passively operated microfluidic device for stimulation and secretion sampling of single pancreatic islets.Analytical chemistry · 2011Article
- Quantitative measurement of zinc secretion from pancreatic islets with high temporal resolution using droplet-based microfluidics.Analytical chemistry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Islet transplantation is a promising therapeutic approach for type 1 diabetes. However, current success rates are low due to progressive graft failure in the long term and inability to monitor graft development in vivo. Other limitations include the necessity of initial invasive surgery and continued immunosuppressive therapy. We report an alternative transplantation strategy with the potential to overcome these problems. This technique involves transplantation of embryonic pancreatic tissue into recipients' subcutaneous space, eliminating the need for invasive surgery and associated risks. Current results in mouse models of type 1 diabetes show that embryonic pancreatic transplants in the subcutaneous space can normalize blood glucose homeostasis and achieve extensive endocrine differentiation and vascularization. Furthermore, modern imaging techniques such as two-photon excitation microscopy (TPEM) can be employed to monitor transplants through the intact skin in a completely noninvasive manner. Thus, this strategy is a convenient alternative to islet transplantation in diabetic mice and has the potential to be translated to human clinical applications with appropriate modifications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.