ArticleChembiochem : a European journal of chemical biology2009
Surface-induced regulation of podosome organization and dynamics in cultured osteoclasts.
Article in Chembiochem : a European journal of chemical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- In vivo effects of different orthodontic loading on root resorption and correlation with mechanobiological stimulus in periodontal ligament.Journal of the Royal Society, Interface · 2019Trial
- Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts.eLife · 2022Article
- The Mechanism Switching the Osteoclast From Short to Long Duration Bone Resorption.Frontiers in cell and developmental biology · 2021Article
- 3D Chitin Scaffolds of Marine Demosponge Origin for Biomimetic Mollusk Hemolymph-Associated BiomineralizationMarine drugs · 2020Article
- L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction.Bone research · 2020Article
- Myosins in Osteoclast Formation and Function.Biomolecules · 2018Review
- Surface microtopography modulates sealing zone development in osteoclasts cultured on bone.Journal of the Royal Society, Interface · 2017Article
- Dynamics of the sealing zone in cultured osteoclasts.Cytoskeleton (Hoboken, N.J.) · 2017Article
- Study of Osteoclast Adhesion to Cortical Bone Surfaces: A Correlative Microscopy Approach for Concomitant Imaging of Cellular Dynamics and Surface Modifications.ACS applied materials & interfaces · 2016Article
- In vitro model of bone to facilitate measurement of adhesion forces and super-resolution imaging of osteoclasts.Scientific reports · 2016Article
- Pit- and trench-forming osteoclasts: a distinction that matters.Bone research · 2015Article
- Tools of the trade: podosomes as multipurpose organelles of monocytic cells.Cellular and molecular life sciences : CMLS · 2015Review
- Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclasts.Acta biomaterialia · 2014Article
- Osteoclasts on bone and dentin in vitro: mechanism of trail formation and comparison of resorption behavior.Calcified tissue international · 2013Article
- Paxillin contracts the osteoclast cytoskeleton.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Effects of surface microtopography on the assembly of the osteoclast resorption apparatus.Journal of the Royal Society, Interface · 2012Article
- Geometry sensing by dendritic cells dictates spatial organization and PGE(2)-induced dissolution of podosomes.Cellular and molecular life sciences : CMLS · 2012Article
- Substrate adhesion regulates sealing zone architecture and dynamics in cultured osteoclasts.PloS one · 2011Article
- Bone is not essential for osteoclast activation.PloS one · 2010Article
- Nano-topography sensing by osteoclasts.Journal of cell science · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Bone is continuously repaired and remodeled through the well-coordinated activity of osteoblasts, which form new bone, and osteoclasts, which resorb it. How osteoclasts sense the properties of the bone surface remains unclear. By combining light and electron microscopy, we compared osteoclast behavior on three distinct surfaces: glass, calcite single crystals, and bone. Podosomes, the basic units of the adhesion structure, and their organization into superstructures were found to be common to cells that were attached to all three substrates, whereas the structure of the resorption organelle, the so-called "ruffled border," markedly differed. Moreover, the integrity, stability, and dynamic behavior of the adhesion superstructures also fundamentally differed, depending on the substrate. We conclude that osteoclasts sense the local properties of the underlying substrate and respond to these signals, both locally and globally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.