ArticleOptics express2008
Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser.
Article in Optics express, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Numerical study of a convective cooling strategy for increasing safe power levels in two-photon brain imaging.Biomedical optics express · 2024Article
- Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis.Science translational medicine · 2016Article
- Simple approach to three-color two-photon microscopy by a fiber-optic wavelength convertor.Biomedical optics express · 2016Article
- In vivo imaging of activated microglia in a mouse model of focal cerebral ischemia by two-photon microscopy.Biomedical optics express · 2015Article
- Coherent fiber supercontinuum for biophotonics.Laser & photonics reviews · 2013Article
- Multiphoton imaging with a direct-diode pumped femtosecond Ti:sapphire laser.Journal of microscopy · 2013Article
- Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Theoretical study of two-photon absorption properties and up-conversion efficiency of new symmetric organic π-conjugated molecules for photovoltaic devices.Journal of molecular modeling · 2012Article
- Simultaneous multiple-excitation multiphoton microscopy yields increased imaging sensitivity and specificity.BMC biotechnology · 2011Article
- Breast cancer: the matrix is the message.The American journal of pathology · 2011Article
- Compact ultrafast semiconductor disk laser: targeting GFP based nonlinear applications in living organisms.Biomedical optics express · 2011Article
- Multiphoton microscopy with near infrared contrast agents.Journal of biomedical opticsArticle
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Authors and funding
9 authors.
Funding
Abstract
Multi-photon microscopy (MPM) is a powerful tool for biomedical imaging, enabling molecular contrast and integrated structural and functional imaging on the cellular and subcellular level. However, the cost and complexity of femtosecond laser sources that are required in MPM are significant hurdles to widespread adoption of this important imaging modality. In this work, we describe femtosecond diode pumped Cr:LiCAF laser technology as a low cost alternative to femtosecond Ti:Sapphire lasers for MPM. Using single mode pump diodes which cost only $150 each, a diode pumped Cr:LiCAF laser generates approximately 70-fs duration, 1.8-nJ pulses at approximately 800 nm wavelengths, with a repetition rate of 100 MHz and average output power of 180 mW. Representative examples of MPM imaging in neuroscience, immunology, endocrinology and cancer research using Cr:LiCAF laser technology are presented. These studies demonstrate the potential of this laser source for use in a broad range of MPM applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.