ArticleThe American journal of surgical pathology2009
Low stage follicular lymphoma: biologic and clinical characterization according to nodal or extranodal primary origin.
Article in The American journal of surgical pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Unusual case of follicular lymphoma of vocal cord.Virchows Archiv : an international journal of pathology · 2026Article
- Clinical features and outcomes of primary ocular adnexal follicular lymphoma: a retrospective analysis.International journal of hematology · 2025Article
- Common Lymphoma in an Uncommon Location.American journal of hematology · 2025Article
- Article
- Characterization of unique B-cell populations in the circulation of people living with HIV prior to non-Hodgkin lymphoma diagnosis.Frontiers in immunology · 2024Article
- Value of GCET1, HGAL (GCET2), and LMO2 in the Determination of Germinal Center Phenotype in Diffuse Large B-cell LymphomaTurkish journal of haematology : official journal of Turkish Society of Haematology · 2023Article
- Genomic and microenvironmental landscape of stage I follicular lymphoma, compared with stage III/IV.Blood advances · 2022Article
- Primary follicular lymphoma of colon: A case series and review of literature.Clinical case reports · 2021Article
- Colorectal follicular lymphoma: A case report.Medicine · 2019Article
- TLR2-activated B cells are phenotypically similar to the abnormal circulating B cells seen preceding the diagnosis of AIDS-related NHL diagnosis.Journal of acquired immune deficiency syndromes (1999) · 2013Article
- Gastrointestinal B-cell lymphomas: From understanding B-cell physiology to classification and molecular pathology.World journal of gastrointestinal oncology · 2012Article
- Comparison of germinal center markers CD10, BCL6 and human germinal center-associated lymphoma (HGAL) in follicular lymphomas.Diagnostic pathology · 2011Article
- Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components.The American journal of surgical pathology · 2010Article
- New developments in the pathology of malignant lymphoma: a review of the literature published from August to December 2008.Journal of hematopathology · 2009Article
- IGH/BCL2 Status Better Predicts Clinico-Pathological Behavior in Primary Splenic Follicular Lymphoma than Histological Grade and Other Molecular Markers.Clinical pathology (Thousand Oaks, Ventura County, Calif.)Article
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13 authors.
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Abstract
Studies suggest that primary extranodal follicular lymphoma (FL) is not infrequent but it remains poorly characterized with variable histologic, molecular, and clinical outcome findings. We compared 27 extranodal FL to 44 nodal FL using morphologic, immunohistochemical, and molecular genetic techniques and evaluated the clinical outcome of these 2 similarly staged groups. Eight cases of primary cutaneous follicle center lymphoma were also studied. In comparison to nodal FL, a greater number of extranodal FL contained a diffuse growth pattern (P=0.004) and lacked CD10 expression (P=0.014). Fifty-four percent of extranodal and 42% of nodal FL cases showed evidence of t(14;18), with minor breakpoints (icr, 3'BCL2, 5'mcr) more commonly found in extranodal cases (P=0.003). Outcome data showed no significant differences in overall survival (P=0.565) and progression-free survival (P=0.627) among extranodal, nodal, and primary cutaneous follicle center lymphoma cases. Analysis of all cases by t(14;18) status indicate that the translocation-negative group is characterized by a diffuse growth pattern (P=0.043) and lower BCL2 expression (P=0.018). The t(14;18)-positive group showed significantly better overall survival (P=0.019) and disease-specific survival (P=0.006) in comparison with the t(14;18)-negative group. In low stage FL, the status of t(14;18) seems to be more predictive of outcome than origin from an extranodal versus nodal site.
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