ArticleAntimicrobial agents and chemotherapy2009
Novel staphylococcal cassette chromosome mec type, tentatively designated type VIII, harboring class A mec and type 4 ccr gene complexes in a Canadian epidemic strain of methicillin-resistant Staphylococcus aureus.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Genomic diversity and resistance determinants of staphylococci from cow and buffalo milk.Molecular biology reports · 2026Article
- Antimicrobial Resistance Profiles andClinical, cosmetic and investigational dermatology · 2024Article
- Deciphering the genomic character of the multidrug-resistantAIMS microbiology · 2024Article
- Phage Therapy as an Alternative Treatment Modality for ResistantAntibiotics (Basel, Switzerland) · 2023Review
- Novel Organization of the Staphylococcal Cassette ChromosomeMicrobiology spectrum · 2022Article
- Molecular Mechanisms of Drug Resistance inInternational journal of molecular sciences · 2022Review
- Current Status of Staphylococcal Cassette ChromosomeAntibiotics (Basel, Switzerland) · 2022Review
- Role of Bioaerosols on the Short-Distance Transmission of Multidrug-Resistant Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- A comparative characterization of nasal and clinical isolates ofIranian journal of microbiology · 2021Article
- Characterizing a Novel Staphylococcal Cassette ChromosomeAntimicrobial agents and chemotherapy · 2021Article
- Molecular Epidemiology of Clinical and Colonizing Methicillin-ResistantFrontiers in veterinary science · 2021Article
- Antimicrobial Resistance and Molecular Characteristics of Methicillin-resistantInfection and drug resistance · 2019Article
- Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.Clinical microbiology reviews · 2018Review
- Factors Contributing to the Evolution ofFrontiers in microbiology · 2018Review
- The prevalence, antibiotic resistance andAntimicrobial resistance and infection control · 2018Article
- The Changing Pattern of Population Structure ofFrontiers in microbiology · 2018Article
- Zinc Resistance within Swine-Associated Methicillin-Resistant Staphylococcus aureus Isolates in the United States Is Associated with Multilocus Sequence Type Lineage.Applied and environmental microbiology · 2017Article
- Detection and Genetic Environment of Pleuromutilin-Lincosamide-Streptogramin A Resistance Genes in Staphylococci Isolated from Pets.Frontiers in microbiology · 2017Article
- Article
- Detection of mecA- and mecC-Positive Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates by the New Xpert MRSA Gen 3 PCR Assay.Journal of clinical microbiology · 2016Article
14 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
Staphylococcal cassette chromosome mec (SCCmec) is a mobile genetic element characterized by flanking terminal direct and, in most cases, inverted repeat sequences, the mec and ccr gene complexes, and their surrounding DNA regions. Unique combinations of the mec and ccr gene complexes generate various SCCmec types. Six SCCmec types have been reported to date. We describe here a novel SCCmec type identified in a Canadian methicillin-resistant Staphylococcus aureus (MRSA) epidemic strain. MRSA clinical isolates were screened for known SCCmec types by multiplex and conventional PCR methods. Three phenotypically and genotypically identical MRSA clinical isolates with a pulsotype identical to CMRSA9 were identified locally and found to be nontypeable by available SCCmec typing schemes. Complete sequencing of the SCCmec element revealed a nucleotide fragment of 32,168 bp integrated at an identical chromosomal integration site (attBscc) at the 3' end of the orfX gene. The nucleotide sequences at the chromosome-SCCmec junction regions were typical of other SCCmec types, but the element harbored a unique combination of class A mec and type 4 ccr gene complexes. Sequence recombination analysis suggested that this unique SCCmec type may be derived from homologous recombination between the previously described SCC(RP62A) of S. epidermidis strain RP62A and SCC composite island of S. epidermidis ATCC 12228, respectively, or via recombination of other staphylococcal strains that carry the same or similar mobile cassettes. We identified a previously undescribed type of SCCmec from isolate C10682, tentatively designated type VIII, and we provide compelling evidence supporting the ability of SCC elements to transfer horizontally or undergo recombination to generate new SCCmec types.
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