ArticleGenetics2009
A targeted gain-of-function screen identifies genes affecting salivary gland morphogenesis/tubulogenesis in Drosophila.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Single-cell analysis of the early Drosophila salivary gland reveals that morphogenetic control involves both the induction and exclusion of gene expression programs.PLoS biology · 2025Article
- The Shot CH1 domain recognises a distinct form of F-actin during Drosophila oocyte determination.Development (Cambridge, England) · 2024Article
- Article
- Transcriptional signature of host shift in the seed beetle Zabrotes subfasciatus.Genetics and molecular biology · 2024Article
- Correct regionalization of a tissue primordium is essential for coordinated morphogenesis.eLife · 2021Article
- A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding.Nature communications · 2021Article
- Exocytosis by vesicle crumpling maintains apical membrane homeostasis during exocrine secretion.Developmental cell · 2021Article
- Scutoids are a geometrical solution to three-dimensional packing of epithelia.Nature communications · 2018Article
- Feedback inhibition of actin on Rho mediates content release from large secretory vesicles.The Journal of cell biology · 2018Article
- Visualization of the Genomic Loci That Are Bound by Specific Multiprotein Complexes by Bimolecular Fluorescence Complementation Analysis on Drosophila Polytene Chromosomes.Methods in enzymology · 2017Article
- Molecular mechanisms of de novo lumen formation.Nature reviews. Molecular cell biology · 2014Review
- A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation.Developmental cell · 2014Article
- Apocrine secretion in Drosophila salivary glands: subcellular origin, dynamics, and identification of secretory proteins.PloS one · 2014Article
- Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin.Nature communications · 2014Article
- Anisotropy of Crumbs and aPKC drives myosin cable assembly during tube formation.Developmental cell · 2012Article
- Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin.Development (Cambridge, England) · 2011Article
- Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans.Genetics · 2011Article
- The Garz Sec7 domain guanine nucleotide exchange factor for Arf regulates salivary gland development in Drosophila.Cellular logistics · 2011Article
- Apical constriction: a cell shape change that can drive morphogenesis.Developmental biology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During development individual cells in tissues undergo complex cell-shape changes to drive the morphogenetic movements required to form tissues. Cell shape is determined by the cytoskeleton and cell-shape changes critically depend on a tight spatial and temporal control of cytoskeletal behavior. We have used the formation of the salivary glands in the Drosophila embryo, a process of tubulogenesis, as an assay for identifying factors that impinge on cell shape and the cytoskeleton. To this end we have performed a gain-of-function screen in the salivary glands, using a collection of fly lines carrying EP-element insertions that allow the overexpression of downstream-located genes using the UAS-Gal4 system. We used a salivary-gland-specific fork head-Gal4 line to restrict expression to the salivary glands, in combination with reporters of cell shape and the cytoskeleton. We identified a number of genes known to affect salivary gland formation, confirming the effectiveness of the screen. In addition, we found many genes not implicated previously in this process, some having known functions in other tissues. We report the initial characterization of a subset of genes, including chickadee, rhomboid1, egalitarian, bitesize, and capricious, through comparison of gain- and loss-of-function phenotypes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.