ArticleGenetics2009
Arabidopsis thaliana genes encoding defense signaling and recognition proteins exhibit contrasting evolutionary dynamics.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Harnessing Natural Diversity and Rational Design for Enhanced Plant Immunity.Plant, cell & environment · 2026Review
- Signaling Pathway Analysis and Downstream Genes Associated with Disease Resistance Mediated byPlants (Basel, Switzerland) · 2026Article
- Article
- Genome-wide identification ofFrontiers in plant science · 2025Article
- Complex Polyploids: Origins, Genomic Composition, and Role of Introgressed Alleles.Systematic biology · 2024Article
- Barley MLA3 recognizes the host-specificity effector Pwl2 from Magnaporthe oryzae.The Plant cell · 2024Article
- Comparison of the pathway structures influencing the temporal response of salicylate and jasmonate defence hormones inFrontiers in plant science · 2022Review
- An Ancestry Perspective of the Evolution of PBS1 Proteins in Plants.International journal of molecular sciences · 2021Article
- Comparative genomic analysis of the Lipase3 gene family in five plant species reveals distinct evolutionary origins.Genetica · 2018Article
- Defended to the Nines: 25 Years of Resistance Gene Cloning Identifies Nine Mechanisms for R Protein Function.The Plant cell · 2018Review
- Genome-wide identification and expression analysis of the BTB domain-containing protein gene family in tomato.Genes & genomics · 2018Article
- Diversification of defensins and NLRs in Arabidopsis species by different evolutionary mechanisms.BMC evolutionary biology · 2017Article
- Evolutionary processes in populations of Cryptosporidium inferred from gp60 sequence data.Parasitology research · 2017Article
- The evolution of ethylene signaling in plant chemical ecology.Journal of chemical ecology · 2014Review
- Recognition of the protein kinase AVRPPHB SUSCEPTIBLE1 by the disease resistance protein RESISTANCE TO PSEUDOMONAS SYRINGAE5 is dependent on s-acylation and an exposed loop in AVRPPHB SUSCEPTIBLE1.Plant physiology · 2014Article
- Comparative analysis of protein-protein interactions in the defense response of rice and wheat.BMC genomics · 2013Article
- The heterogeneous levels of linkage disequilibrium in white spruce genes and comparative analysis with other conifers.Heredity · 2012Article
- Article
- Balancing selection at the tomato RCR3 Guardee gene family maintains variation in strength of pathogen defense.PLoS genetics · 2012Article
- Allelic heterogeneity and trade-off shape natural variation for response to soil micronutrient.PLoS genetics · 2012Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interplay between pathogen effectors, their host targets, and cognate recognition proteins provides various opportunities for antagonistic cycles of selection acting on plant and pathogen to achieve or abrogate resistance, respectively. Selection has previously been shown to maintain diversity in plant proteins involved in pathogen recognition and some of their cognate pathogen effectors. We analyzed the signatures of selection on 10 Arabidopsis thaliana genes encoding defense signal transduction proteins in plants, which are potential targets of pathogen effectors. There was insufficient evidence to reject neutral evolution for 6 genes encoding signaling components consistent with these proteins not being targets of effectors and/or indicative of constraints on their ability to coevolve with pathogen effectors. Functional constraints on effector targets may have provided the driving selective force for the evolution of guard proteins. PBS1, a known target of an effector, showed little variation but is known to be monitored by a variable guard protein. Evidence of selection maintaining diversity was present at NPR1, PAD4, and EDS1. Differences in the signatures of selection observed may reflect the numbers of effectors that target a particular protein, the presence or absence of a cognate guard protein, as well as functional constraints imposed by biochemical activities or interactions with plant proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.