ArticleGenetics2009
Cis-regulatory variation is typically polyallelic in Drosophila.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Cis-regulatory Variation in Relation to Sex and Sexual Dimorphism in Drosophila melanogaster.Genome biology and evolution · 2024Article
- Article
- CompensatoryEvolution letters · 2019Article
- Article
- Gene regulation and speciation in house mice.Genome research · 2016Article
- Dissecting complex traits using the Drosophila Synthetic Population Resource.Trends in genetics : TIG · 2014Review
- Genetic dissection of the Drosophila melanogaster female head transcriptome reveals widespread allelic heterogeneity.PLoS genetics · 2014Article
- Tempo and mode of regulatory evolution in Drosophila.Genome research · 2014Article
- RNA-seq analysis of allele-specific expression, hybrid effects, and regulatory divergence in hybrids compared with their parents from natural populations.Genome biology and evolution · 2013Article
- Allele-specific gene expression in a wild nonhuman primate population.Molecular ecology · 2011Article
- Genomic features that predict allelic imbalance in humans suggest patterns of constraint on gene expression variation.Molecular biology and evolution · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Gene expression levels vary heritably, with approximately 25-35% of the loci affecting expression acting in cis. We characterized standing cis-regulatory variation among 16 wild-derived strains of Drosophila melanogaster. Our experiment's robust biological and technical replication enabled precise estimates of variation in allelic expression on a high-throughput SNP genotyping platform. We observed concordant, significant differential allelic expression (DAE) in 7/10 genes queried with multiple SNPs, and every member of a set of eight additional, one-assay genes suggest significant DAE. Four of the high-confidence, multiple-assay genes harbor three or more statistically distinguishable allelic classes, often at intermediate frequency. Numerous intermediate-frequency, detectable regulatory polymorphisms cast doubt on a model in which cis-acting variation is a product of deleterious mutations of large effect. Comparing our data to predictions of population genetics theory using coalescent simulations, we estimate that a typical gene harbors 7-15 cis-regulatory sites (nucleotides) at which a selectively neutral mutation would elicit an observable expression phenotype. If standing cis-regulatory variation is actually slightly deleterious, the true mutational target size is larger.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.