ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2008
Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- The Role of Circulating Protein and Metabolite Biomarkers in the Development of Pancreatic Ductal Adenocarcinoma (PDAC): A Systematic Review and Meta-analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Pooled it
- The association between IGF1 Gene 3'-UTR polymorphisms and cancer risk: A Meta-analysis.Medicine · 2018Pooled it
- Article
- Methylation of a newly identified region of the INS-IGF2 gene determines IGF2 expression in breast cancer tumors and in breast cancer cells.Oncotarget · 2020Article
- Screening Strategy of Pancreatic Cancer in Patients with Diabetes Mellitus.Diagnostics (Basel, Switzerland) · 2020Review
- Maternal IGF1 and IGF1R polymorphisms and the risk of spontaneous preterm birth.Journal of clinical laboratory analysis · 2017Article
- Gene-by-Environment Interactions in Pancreatic Cancer: Implications for Prevention.The Yale journal of biology and medicine · 2015Review
- miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma.Oncogene · 2015Article
- Association of metabolic syndromes and risk factors with ampullary tumors development: a case-control study in China.World journal of gastroenterology · 2014Article
- Interplay between smoking-induced genotoxicity and altered signaling in pancreatic carcinogenesis.Carcinogenesis · 2012Review
- The bidirectional interation between pancreatic cancer and diabetes.World journal of surgical oncology · 2012Review
- Clinical significance of insulin-like growth factor gene polymorphisms with survival in patients with gastrointestinal stromal tumors.Journal of the Korean Surgical Society · 2012Article
- Diabetes and pancreatic cancer.Molecular carcinogenesis · 2012Article
- No Association of Insulin-like Growth Factor Gene Polymorphisms with Survival in Patients with Colorectal Cancer.Cancer research and treatment · 2011Article
- IGF gene polymorphisms and breast cancer in African-American and Hispanic women.International journal of oncology · 2011Article
- Glucose metabolism gene variants modulate the risk of pancreatic cancer.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- An overview of genetic polymorphisms and pancreatic cancer risk in molecular epidemiologic studies.Journal of epidemiology · 2011Review
- Interaction between IGF-1 polymorphisms and overweight for the risk of pancreatic cancer in Japanese.International journal of molecular epidemiology and genetics · 2011Article
- Robust tests for matched case-control genetic association studies.BMC genetics · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Insulin-like growth factors (IGF) have been associated with risk of common human cancers, but the association between IGFs and pancreatic cancer risk is unclear. To determine whether genetic variations of IGF modify pancreatic cancer risk, we compared the frequency of six single nucleotide polymorphisms of IGF1 and IGF2 in a large-scale case control study. Single nucleotide polymorphisms were investigated using the TaqMan method in 892 patients with pancreatic ductal adenocarcinoma and 783 healthy controls who were recruited from The University of Texas M. D. Anderson Cancer Center from 2000 to 2007. Cases and controls were frequency matched by age (+/-5 years), race, and sex. Risk factor information was collected using direct interviews. We estimated odds ratios (OR) and 95% confidence intervals (95% CI) using unconditional multivariate logistic regression models. A haplotype of IGF1 gene containing the 3'-UTR Ex4 -177 G>C G allele had a significantly lower frequency in cases (0.027) than in controls (0.041; P = 0.039). A statistically significant joint effect of the IGF1 3'-UTR Ex4 -177 G>C C allele and diabetes on pancreatic cancer risk was observed. The OR (95% CI) were 1.07 (0.81-1.42), 2.12 (1.53-2.93), and 5.69 (2.63-12.3) for individuals who had the CC/CG genotype alone, diabetes alone, or both factors, respectively, compared with subjects without either of the two factors with adjustment for other risk factors. The IGF2 3'-UTR Ex4 -233C>T TT genotype was significantly associated with a reduced risk of pancreatic cancer (OR = 0.07; 95% CI = 0.01-0.57; P = 0.013). The polymorphic variants of the IGF genes may serve as a susceptibility factor for pancreatic cancer.
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