ArticleCell host & microbe2008
TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
Article in Cell host & microbe, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 138 citations in OpenAlex.
- A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations.The Journal of clinical investigation · 2017Trial
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- Metabolic mediators: microbial-derived metabolites as key regulators of anti-tumor immunity, immunotherapy, and chemotherapy.Frontiers in immunology · 2024Review
- Investigation of the Effects of Monomeric and Dimeric Stilbenoids on Bacteria-Induced Cytokines and LPS-Induced ROS Formation in Bone Marrow-Derived Dendritic Cells.International journal of molecular sciences · 2023Article
- Dysregulated monocyte-derived macrophage response to Group BFrontiers in immunology · 2023Article
- Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon-stimulated genes signaling during pregnancy.Immunological reviews · 2022Review
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- Cytosolic detection of phagosomal bacteria-Mechanisms underlying PAMP exodus from the phagosome into the cytosol.Molecular microbiology · 2021Review
- De Novo Genome Assembly of Chinese Plateau Honeybee Unravels Intraspecies Genetic Diversity in the Eastern Honeybee,Insects · 2021Article
- Suppression of local type I interferon by gut microbiota-derived butyrate impairs antitumor effects of ionizing radiation.The Journal of experimental medicine · 2021Article
- The immunomodulatory effect of cathelicidin-B1 on chicken macrophages.Veterinary research · 2020Article
- Trophoblast-secreted soluble-PD-L1 modulates macrophage polarization and function.Journal of leukocyte biology · 2020Article
- Beneficial bacteria activate type-I interferon production via the intracellular cytosolic sensors STING and MAVS.Gut microbes · 2020Article
- The interferon stimulated gene viperin, restricts Shigella. flexneri in vitro.Scientific reports · 2019Article
- Relevance of placental type I interferon beta regulation for pregnancy success.Cellular & molecular immunology · 2018Article
- Cyclic GMP-AMP Synthase Is the Cytosolic Sensor ofJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- The Emerging Roles of STING in Bacterial Infections.Trends in microbiology · 2017Review
- cGAS-STING-TBK1-IRF3/7 induced interferon-β contributes to the clearing of non tuberculous mycobacterial infection in mice.Virulence · 2017Article
- Intrinsic Maturational Neonatal Immune Deficiencies and Susceptibility to Group B Streptococcus Infection.Clinical microbiology reviews · 2017Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Type I interferon (IFN) is an important host defense cytokine against intracellular pathogens, mainly viruses. In assessing IFN production in response to group B streptococcus (GBS), we find that IFN-beta was produced by macrophages upon stimulation with both heat-killed and live GBS. Exposure of macrophages to heat-killed GBS activated a Toll-like receptor (TLR)-dependent pathway, whereas live GBS activated a TLR/NOD/RIG-like receptor (RLR)-independent pathway. This latter pathway required bacterial phagocytosis, proteolytic bacterial degradation, and phagolysosomal membrane destruction by GBS pore-forming toxins, leading to the release of bacterial DNA into the cytosol. GBS DNA in the cytosol induced IFN-beta production via a pathway dependent on the activation of the serine-threonine kinase TBK1 and phosphorylation of the transcription factor IRF3. Thus, activation of IFN-alpha/-beta production during infection with GBS, commonly considered an extracellular pathogen, appears to result from the interaction of GBS DNA with a putative intracellular DNA sensor or receptor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.