ArticleMolecular and cellular neurosciences2009
Neuronal Ca2+ sensor VILIP-1 leads to the upregulation of functional alpha4beta2 nicotinic acetylcholine receptors in hippocampal neurons.
Article in Molecular and cellular neurosciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- A brief guideline for the studies of structure-function relationship of ion channels using AlphaFold3.Fundamental research · 2026Review
- Visinin-like protein-1 level is associated with short-term functional outcome of acute ischemic stroke: A prospective cohort study.Medicine · 2020Article
- The MX-Helix of Muscle nAChR Subunits Regulates Receptor Assembly and Surface Trafficking.Frontiers in molecular neuroscience · 2020Article
- Serine residues in the α4 nicotinic acetylcholine receptor subunit regulate surface α4β2Biochemical pharmacology · 2019Article
- Dimerization of Neuronal Calcium Sensor Proteins.Frontiers in molecular neuroscience · 2018Review
- Fischer 344 and Lewis Rat Strains as a Model of Genetic Vulnerability to Drug Addiction.Frontiers in neuroscience · 2016Review
- Determinants in the β and δ subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor.The Journal of biological chemistry · 2014Article
- Article
- Exploring the nicotinic acetylcholine receptor-associated proteome with iTRAQ and transgenic mice.Genomics, proteomics & bioinformatics · 2013Article
- Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors.Neuropharmacology · 2012Article
- Molecular structure and target recognition of neuronal calcium sensor proteins.Biochimica et biophysica acta · 2012Review
- Understanding the physiological roles of the neuronal calcium sensor proteins.Molecular brain · 2012Review
- The visinin-like proteins VILIP-1 and VILIP-3 in Alzheimer's disease-old wine in new bottles.Frontiers in molecular neuroscience · 2012Article
- Molecular structure and target recognition of neuronal calcium sensor proteins.Frontiers in molecular neuroscience · 2012Article
- Unveiling clusters of RNA transcript pairs associated with markers of Alzheimer's disease progression.PloS one · 2012Article
- α6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease.Pharmacological reviews · 2011Review
- Gene expression in accumbens GABA neurons from inbred rats with different drug-taking behavior.Genes, brain, and behavior · 2011Article
- Involvement of VILIP-1 (visinin-like protein) and opposite roles of cyclic AMP and GMP signaling in in vitro cell migration of murine skin squamous cell carcinoma.Molecular carcinogenesis · 2011Article
- Structural analysis of Mg2+ and Ca2+ binding, myristoylation, and dimerization of the neuronal calcium sensor and visinin-like protein 1 (VILIP-1).The Journal of biological chemistry · 2011Article
- Divalent cations and redox conditions regulate the molecular structure and function of visinin-like protein-1.PloS one · 2011Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The neuronal Ca2+-sensor protein VILIP-1, known to affect clathrin-dependent receptor trafficking, has been shown to interact with the cytoplasmic loop of the alpha4-subunit of the alpha4beta2 nicotinic acetylcholine receptor (nAChR), which is the most abundant nAChR subtype with high-affinity for nicotine in the brain. The alpha4beta2 nAChR is crucial for nicotine addiction and the beneficial effects of nicotine on cognition. Its dysfunction has been implicated in frontal lobe epilepsy, Alzheimer's disease and schizophrenia. Here we report that overexpression of VILIP-1 enhances ACh responsiveness, whereas siRNA against VILIP-1 reduces alpha4beta2 nAChR currents of hippocampal neurons. The underlying molecular mechanism likely involves enhanced constitutive exocytosis of alpha4beta2 nAChRs mediated by VILIP-1. The two interaction partners co-localize in a Ca2+-dependent manner with syntaxin-6, a Golgi-SNARE protein involved in trans-Golgi membrane trafficking. Thus, we speculate that regulation of VILIP-1-expression might modulate surface expression of ligand-gated ion channels, such as the alpha4beta2 nAChRs, possibly comprising a novel form of physiological up-regulation of ligand-gated ion channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.