ReviewFrontiers in neuroendocrinology2009
Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).
Review in Frontiers in neuroendocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 300 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
300 citing papers in PubMed, 5 syntheses or guidelines pooled it, 755 citations in OpenAlex.
- The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.Nature genetics · 2023Pooled it
- Only Small Effects of Mindfulness-Based Interventions on Biomarker Levels of Inflammation and Stress: A Preregistered Systematic Review and Two Three-Level Meta-Analyses.International journal of molecular sciences · 2023Pooled it
- Childhood violence exposure and externalizing behaviors: A systematic review of the role of physiological biomarkers.Psychoneuroendocrinology · 2022Pooled it
- Systematic review of sex differences in the relationship between hormones and depression in HIV.Psychoneuroendocrinology · 2022Pooled it
- DHEA as a Biomarker of Stress: A Systematic Review and Meta-Analysis.Frontiers in psychiatry · 2021Pooled it
- The role of long-term hair steroids as diagnostic and intervention-related biomarkers in a multimorbid inpatient sample with posttraumatic stress disorder.European journal of psychotraumatology · 2025Trial
- Digital music and movement intervention to improve health and wellbeing in older adults in care homes: a pilot mixed methods study.BMC geriatrics · 2024Trial
- Effect of Repetitive Transcranial Magnetic Stimulation on Serum Levels of Steroid Adrenal Hormones in Parkinson's Disease: Sex Differences.Bulletin of experimental biology and medicine · 2022Trial
- The Effects of Acceptance and Commitment Therapy (ACT) Intervention on Inflammation and Stress Biomarkers: a Randomized Controlled Trial.International journal of behavioral medicine · 2020Trial
- Increases in fecal testosterone precede increases in fecal dehydroepiandrosterone in wild male mountain gorillas (Gorilla beringei beringei).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Terpenes as Potential Multi-Target Modulators of Chronic Stress-Induced Neuroendocrine-Immune Dysregulation.International journal of molecular sciences · 2026Review
- Pubertal timing predicts resting-state functional connectivity of cortical networks.Developmental cognitive neuroscience · 2026Article
- Chromogranin A and S100A12 protein measurement in hair of pigs: assay validation, changes across different production stages and comparison with other hair biomarkers.Veterinary research communications · 2026Article
- Peri-implant crevicular fluid stress-related biomarkers and psychometric scores in peri-implant health and disease.Clinical oral investigations · 2026Article
- Contemporary Perspectives on Neurobiology and Treatment of Tic Disorders: A Narrative Review.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2026Article
- The sex-specific role of adrenal androgens in youth psychopathology.Translational psychiatry · 2026Article
- Differential associations between early life adversity subtypes and adolescent stress reactivity across neuroendocrine, autonomic, immune, and metabolic systems.Neurobiology of stress · 2026Article
- Links between hormonal and pubertal development, and adolescent females' risk for affective symptoms.Psychoneuroendocrinology · 2026Article
- Dehydroepiandrosterone (DHEA) as a tool for conservation.Environmental monitoring and assessment · 2026Review
- Molecular Mechanisms of Menstrual Cycle-Related Suicide Risk: A Selective Review of Promising Candidate Systems.Biological psychiatry · 2026Review
240 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear. In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are synthesized in the brain, further suggesting a role of these hormones in brain function and development. Despite intensifying research into the biology of DHEA and DHEAS, many questions concerning their mechanisms of action and their potential involvement in neuropsychiatric illnesses remain unanswered. We review and distill the preclinical and clinical data on DHEA and DHEAS, focusing on (i) biological actions and putative mechanisms of action, (ii) differences in endogenous circulating concentrations in normal subjects and patients with neuropsychiatric diseases, and (iii) the therapeutic potential of DHEA in treating these conditions. Biological actions of DHEA and DHEAS include neuroprotection, neurite growth, and antagonistic effects on oxidants and glucocorticoids. Accumulating data suggest abnormal DHEA and/or DHEAS concentrations in several neuropsychiatric conditions. The evidence that DHEA and DHEAS may be fruitful targets for pharmacotherapy in some conditions is reviewed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.