ArticleDevelopmental biology2009
Autonomous turning of cerebellar granule cells in vitro by intrinsic programs.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- The Role of Galanin in Cerebellar Granule Cell Migration in the Early Postnatal Mouse during Normal Development and after Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Moving into shape: cell migration during the development and histogenesis of the cerebellum.Histochemistry and cell biology · 2018Review
- Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development.The journal of physiological sciences : JPS · 2016Review
- Calcium release-dependent actin flow in the leading process mediates axophilic migration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- An instructive role for patterned spontaneous retinal activity in mouse visual map development.Neuron · 2011Article
- Inhibition of cerebellar granule cell turning by alcohol.Neuroscience · 2010Article
- Four distinct phases of basket/stellate cell migration after entering their final destination (the molecular layer) in the developing cerebellum.Developmental biology · 2009Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
External guidance cues play a role in controlling neuronal cell turning in the developing brain, but little is known about whether intrinsic programs are also involved in controlling the turning. In this study, we examined whether granule cells undergo autonomous changes in the direction of migration in the microexplant cultures of the early postnatal mouse cerebellum. We found that granule cells exhibit spontaneous and periodical turning without cell-cell contact and in the absence of external guidance cues. The frequency of turning was increased by stimulating the Ca(2+) influx and the internal Ca(2+) release, or inhibiting the cAMP signaling pathway, while the frequency was reduced by inhibiting the Ca(2+) influx. Granule cell turning in vitro was classified into four distinct modes, which were characterized by the morphological changes in the leading process and the trailing process, such as bifurcating, turning, withdrawing, and changing the polarity. The occurrence of the 1st and 2nd modes of turning was differentially affected by altering the Ca(2+) and cAMP signaling pathways. Collectively, the results demonstrate that intrinsic programs regulate the autonomous turning of cerebellar granule cells in vitro. Furthermore, the results suggest that extrinsic signals play a role as essential modulators of intrinsic programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.